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Main River Cruises Starting In May 2026, 2027 and 2028

Are you planning a river cruise along the Main in May 2026, 2027 or 2028? Choose from 64 unique river cruises with 1,336 departures operated by Main's leading river cruise lines. Easily compare prices, itineraries, inclusions and traveler reviews to find the Main river cruise that best matches your travel style, budget and dates.
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64 River Cruises (1,336 River Cruise Departures)
9 Day German Grandeur (Eastbound) with Avalon River Cruises
River Cruise
 (1)

9 Days Basel to Nuremberg
Cruise Line: Avalon River Cruises
Ships: Avalon Tranquility II, Avalon Imagery II
Departures: May 2026 to Oct 2027
Rivers: Rhine, Main
Visit: Switzerland, France, Germany
Exclusive Savings
Inside
-
River View
$3,695
Balcony
$5,779
Suite
$7,863
From
US$3,695
Save 1,392
Per Person
View Trip
11 Day German Grandeur with Munich (Eastbound) with Avalon River Cruises
River Cruise
 (1)

11 Days Basel to Munich
Cruise Line: Avalon River Cruises
Ships: Avalon Tranquility II, Avalon Imagery II
Departures: May 2026 to Oct 2027
Rivers: Rhine, Main
Visit: Switzerland, France, Germany
Exclusive Savings
Inside
-
River View
$4,606
Balcony
$6,690
Suite
$8,774
From
US$4,606
Save 1,430
Per Person
View Trip
11 Day Rhine & Main Explorer with Viking River Cruises
New ReleaseRiver Cruise

11 Days Basel to Nuremberg
Cruise Line: Viking River Cruises
Ships: Viking Modi, Viking Skirnir
Departures: May 2026 to Nov 2027
Rivers: Rhine, Main
Visit: Switzerland, France, Germany
Multiple Deals Available
Inside
-
River View
$3,199
Balcony
$3,699
Suite
$5,499
From
US$3,199
Save 500
Per Person
View Trip
8 Day Three-Rivers Cruise with Amadeus River Cruises
New ReleaseRiver Cruise

8 Days Amsterdam to Nuremberg
Cruise Line: Amadeus River Cruises
Ships: Amadeus Cara, Amadeus Amara, Amadeus Mira
Departures: May 2026 to Aug 2027
Rivers: Rhine, Main
Visit: Holland, Germany
Inside
-
River View
$3,038
Balcony
$3,711
Suite
$5,519
From
US$3,038
Per Person
View Trip
8 Day Medieval Treasures with AmaWaterways
New ReleaseRiver Cruise

8 Days Basel to Nuremberg
Cruise Line: AmaWaterways
Ships: AmaCerto, AmaPrima
Departures: Mar 2027 to Oct 2027
Rivers: Rhine, Main
Visit: Switzerland, France, Germany
Exclusive Savings
Inside
-
River View
$3,159
Balcony
$4,694
Suite
$7,190
From
US$3,159
Save 1,400
Per Person
View Trip
11 Day Rhine & Main Explorer with Viking River Cruises
New ReleaseRiver Cruise

11 Days Nuremberg to Basel
Cruise Line: Viking River Cruises
Ships: Viking Modi, Viking Skirnir
Departures: Apr 2026 to Nov 2027
Rivers: Main, Rhine
Visit: Germany, France, Switzerland
Multiple Deals Available
Inside
-
River View
$3,199
Balcony
$3,699
Suite
$4,999
From
US$3,199
Save 400
Per Person
View Trip
8 Day Europe's Rivers & Castles with AmaWaterways
New ReleaseRiver Cruise

8 Days Nuremberg to Luxembourg
Cruise Line: AmaWaterways
Ships: AmaCerto, AmaPrima
Departures: Sep 2026 to Oct 2027
Rivers: Main, Moselle
Visit: Germany, Luxembourg
Exclusive Savings
Inside
-
River View
$4,311
Balcony
$5,846
Suite
$8,342
From
US$4,311
Save 920
Per Person
View Trip
14 Day Romantic Capitals: Paris to Prague - Eastbound with Tauck
New ReleaseRiver Cruise

14 Days Paris to Prague
Cruise Line: Tauck
Departures: May 2026 to Sep 2027
Rivers: Moselle, Main
Visit: France, Luxembourg, Germany, Czech Republic
Inside
-
River View
$10,790
Balcony
$11,240
Suite
$13,790
From
US$10,790
Per Person
View Trip
15 Day Grand European Tour with Viking River Cruises
River Cruise
 (25)

15 Days Amsterdam to Budapest
Cruise Line: Viking River Cruises
Ships: Viking Baldur, Viking Bragi (+15 more), Viking Egdir, Viking Eldir, Viking Gefjon, Viking Gymir, Viking Haki, Viking Lif, Viking Magni, Viking Mimir, Viking Rota, Viking Skadi, Viking Tir, Viking Vali, Viking Ve, Viking Vidar, Viking Vili
Departures: Mar 2026 to Nov 2028
Rivers: Rhine, Main, Danube
Visit: Holland, Germany, Austria, Hungary
Multiple Deals Available
Inside
-
River View
$4,999
Balcony
$5,999
Suite
$8,499
From
US$4,999
Save 1,500
Per Person
View Trip
15 Day Magnificent Europe with Avalon River Cruises
River Cruise
 (81)

15 Days Amsterdam to Budapest
Cruise Line: Avalon River Cruises
Ships: Avalon Expression, Avalon Illumination (+2 more), Avalon Impression, Avalon Passion
Departures: May 2026 to Oct 2027
Rivers: Rhine, Main, Danube
Visit: Holland, Germany, Austria, Hungary
Exclusive Savings
Inside
-
River View
$5,783
Balcony
$8,566
Suite
$12,214
From
US$5,783
Save 2,224
Per Person
View Trip
15 Day Magnificent Rivers of Europe with Avalon River Cruises
River Cruise
 (61)

15 Days Budapest to Amsterdam
Cruise Line: Avalon River Cruises
Ships: Avalon Expression, Avalon Illumination, Avalon Impression
Departures: May 2026 to Oct 2027
Rivers: Danube, Main, Rhine
Visit: Hungary, Slovakia, Austria, Germany, Holland
Exclusive Savings
Inside
-
River View
$5,783
Balcony
$8,566
Suite
$12,214
From
US$5,783
Save 2,224
Per Person
View Trip
15 Day Grand European Tour with Viking River Cruises
River Cruise
 (15)

15 Days Budapest to Amsterdam
Cruise Line: Viking River Cruises
Ships: Viking Baldur, Viking Bragi (+15 more), Viking Egdir, Viking Eldir, Viking Gefjon, Viking Gymir, Viking Haki, Viking Lif, Viking Magni, Viking Mimir, Viking Rota, Viking Skadi, Viking Tir, Viking Vali, Viking Ve, Viking Vidar, Viking Vili
Departures: Apr 2026 to Nov 2028
Rivers: Danube, Main, Rhine
Visit: Hungary, Austria, Germany, Holland
Multiple Deals Available
Inside
-
River View
$4,999
Balcony
$5,999
Suite
$8,499
From
US$4,999
Save 4,500
Per Person
View Trip
15 Day Jewels of Europe with Scenic
River Cruise
 (11)

15 Days Amsterdam to Budapest
Cruise Line: Scenic
Ships: Scenic Amber, Scenic Crystal (+6 more), Scenic Jade, Scenic Jasper, Scenic Jewel, Scenic Opal, Scenic Ruby, Scenic Pearl
Departures: Mar 2026 to Nov 2027
Rivers: Rhine, Main, Danube
Visit: Holland, Germany, Austria, Czech Republic, Slovakia, Hungary
Multiple Deals Available
Inside
-
River View
$7,425
Balcony
$9,563
Suite
$12,767
From
US$7,425
Save 1,621
Per Person
View Trip
15 Day Splendours of Europe with Emerald Cruises
River Cruise
 (4)

15 Days Amsterdam to Budapest
Cruise Line: Emerald Cruises
Ships: Emerald Astra, Emerald Dawn (+5 more), Emerald Destiny, Emerald Luna, Emerald Sky, Emerald Star, Emerald Sun
Departures: Apr 2026 to Nov 2027
Rivers: Rhine, Main, Danube
Visit: Holland, Germany, Austria, Slovakia, Hungary
Multiple Deals Available
Inside
-
River View
$4,374
Balcony
$5,957
Suite
$8,505
From
US$4,374
Save 1,183
Per Person
View Trip
24 Day Ultimate European Journey with Uniworld River Cruises
River Cruise
 (9)

24 Days Amsterdam to Bucharest
Cruise Line: Uniworld River Cruises
Ships: S.S. Marlene, River Duchess
Departures: Jun 2026 to Jun 2027
Rivers: Rhine, Main, Danube
Visit: Holland, Germany, Austria, Hungary (+4 more), Croatia, Serbia, Bulgaria, Romania
Exclusive Savings
Inside
-
River View
$11,262
Balcony
$13,509
Suite
$19,902
From
US$11,262
Save 1,818
Per Person
View Trip
15 Day European Jewels with Uniworld River Cruises
River Cruise
 (8)

15 Days Budapest to Amsterdam
Cruise Line: Uniworld River Cruises
Ships: S.S. Marlene, River Duchess, S.S. Beatrice
Departures: Jun 2026 to Sep 2027
Rivers: Danube, Main, Rhine
Visit: Hungary, Austria, Germany, Holland
Exclusive Savings
Inside
-
River View
$5,730
Balcony
$8,514
Suite
$12,116
From
US$7,364
Save 1,190
Per Person
View Trip
15 Day European Jewels with Uniworld River Cruises
River Cruise
 (5)

15 Days Amsterdam to Budapest
Cruise Line: Uniworld River Cruises
Ships: S.S. Marlene, River Duchess, S.S. Beatrice
Departures: Jun 2026 to Sep 2027
Rivers: Rhine, Main, Danube
Visit: Holland, Germany, Austria, Hungary
Exclusive Savings
Inside
-
River View
$6,738
Balcony
$8,141
Suite
$12,116
From
US$6,932
Save 1,135
Per Person
View Trip
15 Day Jewels of Europe with Scenic
River Cruise
 (5)

15 Days Budapest to Amsterdam
Cruise Line: Scenic
Ships: Scenic Amber, Scenic Crystal (+5 more), Scenic Jade, Scenic Jasper, Scenic Jewel, Scenic Opal, Scenic Ruby
Departures: Mar 2026 to Nov 2027
Rivers: Danube, Main, Rhine
Visit: Hungary, Slovakia, Austria, Czech Republic, Germany, Holland
Multiple Deals Available
Inside
-
River View
$7,206
Balcony
$9,717
Suite
$12,179
From
US$7,206
Save 1,621
Per Person
View Trip
24 Day Ultimate European Journey with Uniworld River Cruises
River Cruise
 (5)

24 Days Bucharest to Amsterdam
Cruise Line: Uniworld River Cruises
Ships: River Duchess, S.S. Beatrice, S.S. Marlene
Departures: May 2026 to May 2027
Rivers: Danube, Main, Rhine
Visit: Romania, Bulgaria, Serbia, Croatia (+4 more), Hungary, Austria, Germany, Holland
Exclusive Savings
Inside
-
River View
$12,169
Balcony
$14,589
Suite
-
From
US$12,169
Save 1,880
Per Person
View Trip
23 Day European Sojourn with Viking River Cruises
River Cruise
 (3)

23 Days Bucharest to Amsterdam
Cruise Line: Viking River Cruises
Ships: Viking Eldir, Viking Lif, Viking Vidar
Departures: May 2027 to Oct 2027
Rivers: Danube, Main, Rhine
Visit: Romania, Bulgaria, Serbia, Croatia (+4 more), Hungary, Austria, Germany, Holland
Flights Included
Exclusive Savings
Inside
-
River View
$9,499
Balcony
$11,599
Suite
$22,999
From
US$9,499
Save 1,000
Per Person
View Trip
23 Day From Romania to the North Sea with Avalon River Cruises
New ReleaseRiver Cruise
 (3)

23 Days Oltenita to Amsterdam
Cruise Line: Avalon River Cruises
Ship: Avalon Illumination
Departure: 08 May 2026
Rivers: Rhine, Main, Danube
Visit: Holland, Germany, Austria, Hungary (+4 more), Croatia, Serbia, Bulgaria, Romania
Exclusive Savings
Inside
-
River View
-
Balcony
$17,947
Suite
-
From
US$12,532
Save 492
Per Person
View Trip
15 Day Splendours of Europe with Emerald Cruises
River Cruise
 (3)

15 Days Budapest to Amsterdam
Cruise Line: Emerald Cruises
Ships: Emerald Astra, Emerald Dawn (+5 more), Emerald Destiny, Emerald Luna, Emerald Sky, Emerald Star, Emerald Sun
Departures: Apr 2026 to Nov 2027
Rivers: Danube, Main, Rhine
Visit: Hungary, Slovakia, Austria, Germany, Holland
Multiple Deals Available
Inside
-
River View
$4,374
Balcony
$5,957
Suite
$8,505
From
US$4,374
Save 1,183
Per Person
View Trip
23 Day European Sojourn with Viking River Cruises
River Cruise
 (1)

23 Days Amsterdam to Bucharest
Cruise Line: Viking River Cruises
Ships: Viking Eldir, Viking Lif, Viking Vidar
Departures: May 2027 to Oct 2027
Rivers: Rhine, Main, Danube
Visit: Holland, Germany, Austria, Hungary (+4 more), Croatia, Serbia, Bulgaria, Romania
Flights Included
Inside
-
River View
$9,499
Balcony
$11,499
Suite
$22,999
From
US$9,499
Per Person
View Trip
22 Day Iconic Rivers of Europe - the Rhine, Main & Danube with Avalon River Cruises
River Cruise
 (1)

22 Days Amsterdam to Oltenita
Cruise Line: Avalon River Cruises
Ships: Avalon Expression, Avalon Impression, Avalon Passion
Departures: Jul 2026 to Aug 2027
Rivers: Rhine, Main, Danube
Visit: Holland, Germany, Austria, Hungary (+4 more), Croatia, Serbia, Bulgaria, Romania
Exclusive Savings
Inside
-
River View
$10,162
Balcony
$14,768
Suite
-
From
US$10,162
Save 2,892
Per Person
View Trip
19 Day Jewels of Europe with Zagreb & Ljubljana with Scenic
New ReleaseRiver Cruise
 (1)

19 Days Zagreb to Amsterdam
Cruise Line: Scenic
Ships: Scenic Jade, Scenic Jasper
Departures: May 2027 to Sep 2027
Rivers: Danube, Main, Rhine
Visit: Croatia, Slovenia, Hungary, Slovakia (+4 more), Austria, Czech Republic, Germany, Holland
Multiple Deals Available
Inside
-
River View
$10,529
Balcony
$13,039
Suite
$15,283
From
US$10,529
Save 1,671
Per Person
View Trip
24 Day Jewels of Europe with Eastern Europe Explorer with Scenic
River Cruise

24 Days Prague to Amsterdam
Cruise Line: Scenic
Ships: Scenic Crystal, Scenic Jade (+3 more), Scenic Jewel, Scenic Opal, Scenic Ruby
Departures: May 2026 to Sep 2027
Rivers: Danube, Main, Rhine
Visit: Czech Republic, Germany, Poland, Hungary, Slovakia, Austria, Holland
Multiple Deals Available
Inside
-
River View
$13,822
Balcony
$16,332
Suite
$18,576
From
US$13,822
Save 1,781
Per Person
View Trip
25 Day Eastern European Escapade & Splendours of Europe with Emerald Cruises
River Cruise
 (2)

25 Days Prague to Amsterdam
Cruise Line: Emerald Cruises
Ships: Emerald Astra, Emerald Dawn (+4 more), Emerald Luna, Emerald Sky, Emerald Star, Emerald Sun
Departures: May 2026 to Oct 2027
Rivers: Danube, Main, Rhine
Visit: Czech Republic, Germany, Poland, Hungary, Slovakia, Austria, Holland
Multiple Deals Available
Inside
-
River View
$9,227
Balcony
$10,810
Suite
$13,358
From
US$9,227
Save 1,289
Per Person
View Trip
8 Day Rhine & Danube Symphony with Amadeus River Cruises
New ReleaseRiver Cruise

8 Days Cologne to Passau
Cruise Line: Amadeus River Cruises
Ships: Amadeus Mira, Amadeus Riva (+2 more), Amadeus Aurea, Amadeus Nova
Departures: Jun 2026 to Sep 2027
Rivers: Rhine, Main, Danube
Visit: Germany
Inside
-
River View
$2,422
Balcony
$3,169
Suite
$4,394
From
US$2,422
Per Person
View Trip
24 Day From Romania to the North Sea with Bucharest with Avalon River Cruises
New ReleaseRiver Cruise

24 Days Bucharest to Amsterdam
Cruise Line: Avalon River Cruises
Ship: Avalon Illumination
Departure: 07 May 2026
Rivers: Rhine, Main, Danube
Visit: Romania, Bulgaria, Serbia, Croatia (+4 more), Hungary, Austria, Germany, Holland
Exclusive Savings
Inside
-
River View
-
Balcony
$18,148
Suite
-
From
US$12,733
Save 500
Per Person
View Trip
19 Day Jewels of Europe with Ljubljana & Zagreb with Scenic
River Cruise

19 Days Amsterdam to Zagreb
Cruise Line: Scenic
Ships: Scenic Crystal, Scenic Jade
Departures: May 2026 to Jul 2027
Rivers: Rhine, Main, Danube
Visit: Holland, Germany, Austria, Czech Republic (+4 more), Slovakia, Hungary, Slovenia, Croatia
Multiple Deals Available
Inside
-
River View
$10,529
Balcony
$13,039
Suite
$15,283
From
US$10,529
Save 1,306
Per Person
View Trip
Results: 1-30 of 64

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