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Mediterranean Luxury Cruises

Explore the best luxury cruises sailing in and around the Mediterranean. Choose from 605 unique cruise itineraries with 2 past traveler reviews from 10 leading cruise lines. September is the most popular month to join a luxury cruise sailing in and around the Mediterranean with 652 departures starting between February 2026 and October 2028.
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605 Cruises (652 Cruise Departures)
8 Day Culinary Towns & Villages with Regent Seven Seas
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 13 November 2027
Visit: Spain, France, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,206
Suite
$6,186
From
US$5,206
Save 10,392
Per Person
View Trip
11 Day Culinary Wonders with Regent Seven Seas
Cruise

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 07 August 2027
Visit: Italy, Monaco, France, Spain, Morocco, Portugal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,743
Suite
$9,870
From
US$8,743
Save 15,055
Per Person
View Trip
8 Day Ancient Sites & Cities with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 05 November 2026
Visit: Italy, Sicily, Malta, Greece, Turkey
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
$1,955
Balcony
$2,822
Suite
$3,894
From
US$1,955
Save 2,643
Per Person
View Trip
8 Day Luminous Mediterranean with Oceania Cruises
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 31 October 2026
Visit: Spain, France, Italy
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,245
Suite
$4,488
From
US$3,245
Save 3,753
Per Person
View Trip
12 Day Islands of the Mediterranean with Scenic
New ReleaseCruise

12 Days (11 Nights) Athens to Malaga
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 28 June 2026
Visit: Greece, Sicily, Sardinia, Spain
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$34,928
From
US$34,928
Save 43,162
Per Person
View Trip
8 Day Ancient Cities of the Mediterranean with Ponant
Cruise

8 Days (7 Nights) Athens to Valletta
Cruise Line: Ponant
Ship: Le Dumont d’Urville
Departure: 22 October 2026
Visit: Greece, Italy, Sicily, Malta
Inside
-
Oceanview
-
Balcony
$6,260
Suite
$11,700
From
US$6,260
Per Person
View Trip
7 Day Monte Carlo to Barcelona with Silversea
Cruise

7 Days (6 Nights) Monte Carlo to Barcelona
Cruise Line: Silversea
Ship: Silver Ray
Departure: 21 June 2026
Visit: Monaco, France, Spain
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,440
Suite
$6,840
From
US$4,440
Save 2,960
Per Person
View Trip
15 Day Iberia & Italian Treasures with Oceania Cruises
Cruise
 (1)

15 Days (14 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 21 December 2026
Visit: Portugal, Spain, France, Italy, Corsica
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$3,577
Oceanview
$3,907
Balcony
$5,968
Suite
$8,277
From
US$3,577
Save 5,021
Per Person
View Trip
12 Day Stars Of Iberia with Regent Seven Seas
Cruise

12 Days (11 Nights) Lisbon to Valletta
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 09 October 2026
Visit: Portugal, Spain, Sardinia, Tunisia, Sicily, Malta
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,849
Suite
$11,780
From
US$10,849
Save 16,649
Per Person
View Trip
10 Day Tyrrhenian Yacht Treasures with Seabourn
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Seabourn Venture
Departure: 05 May 2026
Visit: Italy, Sicily, Sardinia, Corsica, Spain
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$10,846
From
US$10,846
Save 203
Per Person
View Trip
16 Day Civitavecchia to Barcelona with Silversea
Cruise

16 Days (15 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Ray
Departure: 09 August 2026
Visit: Italy, France, Monaco, Spain
All-Inclusive Fare
Inside
-
Oceanview
-
Balcony
$8,100
Suite
$13,500
From
US$8,100
Per Person
View Trip
19 Day Ultimate Mediterranean in Depth with Scenic
New ReleaseCruise

19 Days (18 Nights) Palma de Mallorca to Nice
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 03 May 2027
Visit: Spain, Sardinia, Sicily, Malta (+4 more), Italy, Corsica, France, Monaco
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$49,133
Suite
$75,808
From
US$49,133
Save 1,447
Per Person
View Trip
8 Day Yachting Havens with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 05 May 2026
Visit: Spain, France, Italy
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
$4,580
Balcony
-
Suite
$9,430
From
US$4,580
Save 4,818
Per Person
View Trip
11 Day The Hidden Wonders of the Mediterranean with Scenic
New ReleaseCruise

11 Days (10 Nights) Valletta to Lisbon
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 06 July 2027
Visit: Malta, Sicily, Sardinia, Spain, Morocco, Portugal
Wave Offer
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,251
Suite
$17,586
From
US$12,251
Save 19,039
Per Person
View Trip
11 Day Barcelona to Monte Carlo with Silversea
Cruise

11 Days (10 Nights) Barcelona to Monte Carlo
Cruise Line: Silversea
Ship: Silver Ray
Departure: 28 September 2026
Visit: Spain, France, Monaco
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,070
Suite
$9,360
From
US$7,070
Save 3,030
Per Person
View Trip
8 Day Italy, France & Spain Cruise: Florence, Nice & Barcelona with Azamara Cruises
Cruise
 (8)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 27 May 2027
Visit: Italy, France, Spain
Azamara Always Included
Inside
$2,099
Oceanview
$2,347
Balcony
$3,084
Suite
$4,917
From
US$2,099
Per Person
View Trip
16 Day Malta, Italy, Spain & Portugal with Seabourn
Cruise

16 Days (15 Nights) Athens to Lisbon
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 30 October 2027
Visit: Greece, Malta, Sicily, Sardinia, Spain, Portugal
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,109
Suite
$15,107
From
US$9,109
Save 155
Per Person
View Trip
10 Day Spain Intensive Cruise: Seville, Malaga & Barcelona with Azamara Cruises
Cruise
 (3)

10 Days (9 Nights) Lisbon to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 20 September 2027
Visit: Portugal, Spain, Gibraltar
Azamara Always Included
Exclusive Savings
Inside
$3,061
Oceanview
$3,410
Balcony
$4,312
Suite
$6,379
From
US$3,061
Save 68
Per Person
View Trip
6 Day An Autumn Escape: Côte d’Azur, Italian Riviera & Corsica with Ponant
Cruise
 (1)

6 Days (5 Nights) Nice to Florence
Cruise Line: Ponant
Ship: Le Boreal
Departure: 28 September 2027
Visit: France, Italy, Corsica
Inside
-
Oceanview
$3,940
Balcony
$4,150
Suite
$7,720
From
US$3,940
Per Person
View Trip
8 Day Civitavecchia (Rome) to Monte Carlo with Silversea
Cruise

8 Days (7 Nights) Rome to Monte Carlo
Cruise Line: Silversea
Ship: Silver Ray
Departure: 03 July 2027
Visit: Italy, Sardinia, Corsica, France, Monaco
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,800
Suite
$8,100
From
US$4,800
Save 3,200
Per Person
View Trip
13 Day Passage To Portugal with Oceania Cruises
Cruise
 (1)

13 Days (12 Nights) Monte Carlo to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 12 July 2026
Visit: Monaco, France, Spain, Gibraltar, Morocco, Portugal
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$3,521
Oceanview
$3,870
Balcony
$5,834
Suite
$7,886
From
US$3,521
Save 4,477
Per Person
View Trip
15 Day Southern Mediterranean Sojourn with Regent Seven Seas
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Navigator
Departure: 07 December 2026
Visit: Spain, France, Italy, Sicily, Tunisia, Malta
Exclusive Savings
Inside
-
Oceanview
$6,298
Balcony
$8,160
Suite
$9,434
From
US$6,298
Save 13,500
Per Person
View Trip
8 Day Western Mediterranean with Cunard
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 10 August 2026
Visit: Italy, Spain, France
Inside
$1,869
Oceanview
$2,009
Balcony
$2,439
Suite
$4,409
From
US$1,869
Per Person
View Trip
8 Day Barcelona to Civitavecchia (Rome) with Silversea
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Nova
Departure: 14 November 2027
Visit: Spain, France, Italy
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,380
Suite
$5,480
From
US$4,380
Save 2,920
Per Person
View Trip
18 Day Discover Cultural Treasures with Emerald Cruises
New ReleaseCruise
 (3)

18 Days (17 Nights) Tenerife to Nice
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 08 April 2026
Visit: Spain, Morocco, Corsica, Italy, France
Fly Free Economy
Fly Free Premium Economy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$18,527
From
US$18,527
Save 19,603
Per Person
View Trip
8 Day Etruscan Waterways with Oceania Cruises
Cruise
 (3)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 21 April 2026
Visit: Spain, France, Italy, Corsica, Sardinia
Your World Inclusions
Exclusive Savings
Inside
$2,735
Oceanview
$3,172
Balcony
$3,657
Suite
-
From
US$2,735
Save 2,863
Per Person
View Trip
8 Day Under Sail from the Riviera to Sicily with Ponant
Cruise

8 Days (7 Nights) Nice to Palermo
Cruise Line: Ponant
Ship: Le Ponant
Departure: 01 June 2027
Visit: France, Italy, Sicily
Inside
-
Oceanview
$10,700
Balcony
$17,240
Suite
$19,210
From
US$10,700
Per Person
View Trip
10 Day Spanish Shores & Beyond with Emerald Cruises
New ReleaseCruise

10 Days (9 Nights) Barcelona to Palma de Mallorca
Cruise Line: Emerald Cruises
Ship: Emerald Sakara
Departure: 10 September 2026
Visit: Spain, France, Monaco, Corsica, Sardinia
Wave Offer
Early Payment Discount
Exclusive Savings
Inside
-
Oceanview
$6,029
Balcony
-
Suite
$8,599
From
US$6,029
Save 8,961
Per Person
View Trip
12 Day Best Of The Mediterranean Cruise: La Goulette, Valletta & Siracusa with Azamara Cruises
Cruise
 (3)

12 Days (11 Nights) Athens to Athens
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 15 February 2028
Visit: Greece, Egypt, Cyprus, Turkey
Azamara Always Included
Exclusive Savings
Inside
$3,858
Oceanview
$4,518
Balcony
$5,352
Suite
$7,360
From
US$3,858
Save 91
Per Person
View Trip
19 Day Mediterranean & North Africa Voyage: Portugal, Morocco & Italy with Azamara Cruises
Cruise
 (8)

19 Days (18 Nights) Lisbon to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 17 November 2026
Visit: Portugal, Morocco, Spain, Gibraltar, France, Italy
Azamara Always Included
Exclusive Savings
Inside
$3,852
Oceanview
$4,240
Balcony
$5,191
Suite
$8,130
From
US$3,852
Save 67
Per Person
View Trip
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