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Mediterranean Luxury Cruises

Explore the best luxury cruises sailing in and around the Mediterranean. Choose from 780 unique cruise itineraries with 1760 past traveler reviews from 10 leading cruise lines. September is the most popular month to join a luxury cruise sailing in and around the Mediterranean with 900 departures starting between May 2026 and April 2029.
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780 Cruises (900 Cruise Departures)
12 Day Civitavecchia (Rome) to Lavrion (Athens) with Silversea
Cruise
 (1)

12 Days (11 Nights) Rome to Athens
Cruise Line: Silversea
Ship: Silver Nova
Departure: 24 June 2026
Visit: Italy, Sicily, Malta, Greece
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,600
Suite
$15,600
From
US$10,600
Save 1,500
Per Person
View Trip
8 Day Italy, France & Spain Cruise: Rome, Florence & Barcelona with Azamara Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 15 May 2027
Visit: Italy, Monaco, France, Spain
Azamara Always Included
Inside
$1,919
Oceanview
$2,209
Balcony
$2,919
Suite
$4,709
From
US$1,919
Per Person
View Trip
15 Day Spain, Italy And Adriatic with Cunard
Cruise
 (13)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 28 May 2027
Visit: Italy, Malta, Montenegro, Croatia, Sicily, Spain
Bonus Onboard Credit
Value Fare
Inside
$2,439
Oceanview
$2,679
Balcony
$3,129
Suite
$6,409
From
US$2,439
Per Person
View Trip
8 Day Spain Intensive Cruise: Malaga, Valencia & Barcelona with Azamara Cruises
Cruise
 (3)

8 Days (7 Nights) Malaga to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 17 April 2027
Visit: Spain, Gibraltar
Azamara Always Included
Inside
$2,179
Oceanview
$2,489
Balcony
$3,279
Suite
$5,259
From
US$2,179
Per Person
View Trip
15 Day Adriatic & Aegean Radiance with Oceania Cruises
Cruise
 (2)

15 Days (14 Nights) Monte Carlo to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Regatta
Departure: 17 July 2026
Visit: Monaco, Sicily, Malta, Croatia, Montenegro, Greece, Turkey
Memorial Day Sale
Your World Inclusions
Exclusive Savings
Inside
$3,710
Oceanview
$3,780
Balcony
$6,055
Suite
$7,805
From
US$3,710
Save 6,888
Per Person
View Trip
10 Day Seascapes & Gastronomy with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Venice
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 06 October 2027
Visit: Italy, Sicily, Malta, Greece, Albania, Montenegro, Croatia
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$2,499
Oceanview
$2,849
Balcony
$4,399
Suite
$6,199
From
US$2,499
Save 2,499
Per Person
View Trip
15 Day Mediterranean And Adriatic with Cunard
Cruise
 (13)

15 Days (14 Nights) Trieste to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 18 August 2028
Visit: Italy, Croatia, Greece, Sicily, Spain, France
Cunard Fare
Value Fare
Inside
$2,999
Oceanview
$3,359
Balcony
$3,944
Suite
$7,409
From
US$2,999
Per Person
View Trip
8 Day Greece & Italy Cruise: Olympia, Catania & Amalfi Coast (salerno) with Azamara Cruises
Cruise
 (3)

8 Days (7 Nights) Athens to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 26 February 2028
Visit: Greece, Sicily, Italy
Azamara Always Included
Inside
$1,539
Oceanview
$1,949
Balcony
$2,549
Suite
$3,879
From
US$1,539
Per Person
View Trip
15 Day Spain Intensive Combination Cruise: Seville, Malaga & Valencia with Azamara Cruises
Cruise
 (3)

15 Days (14 Nights) Lisbon to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 25 March 2028
Visit: Portugal, Spain, Morocco, Gibraltar
Azamara Always Included
Inside
$3,389
Oceanview
$3,649
Balcony
$4,479
Suite
$6,269
From
US$3,389
Per Person
View Trip
8 Day Mediterranean Vistas with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Venice
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 03 August 2026
Visit: Italy, Sicily, Greece, Montenegro, Croatia, Slovenia
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$2,749
Oceanview
$2,999
Balcony
$4,399
Suite
$9,199
From
US$2,749
Save 2,749
Per Person
View Trip
11 Day Ancient Shores of the Mediterranean with Ponant
Cruise
 (1)

11 Days (10 Nights) Valletta to Malaga
Cruise Line: Ponant
Ship: Le Bougainville
Departure: 31 October 2026
Visit: Malta, Sicily, Tunisia, Algeria, Spain
Inside
-
Oceanview
-
Balcony
$9,860
Suite
$16,710
From
US$9,860
Per Person
View Trip
9 Day France, Monaco & Italy Cruise: Cannes, Monte Carlo & Portofino with Azamara Cruises
Cruise
 (3)

9 Days (8 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 15 September 2028
Visit: Spain, France, Monaco, Italy
Azamara Always Included
Inside
$2,019
Oceanview
$2,189
Balcony
$2,699
Suite
$3,809
From
US$2,019
Per Person
View Trip
22 Day Italy, Greece & Turkey Cruise: Rome, Venice & Athens with Azamara Cruises
Cruise
 (3)

22 Days (21 Nights) Barcelona to Athens
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 31 October 2027
Visit: Spain, Italy, Sicily, Montenegro (+4 more), Croatia, Greece, Cyprus, Turkey
Azamara Always Included
Inside
$8,389
Oceanview
$10,309
Balcony
$12,609
Suite
$18,409
From
US$8,389
Per Person
View Trip
15 Day Istanbul And Greek Islands with Cunard
Cruise
 (1)

15 Days (14 Nights) Rome to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 21 September 2026
Visit: Italy, Sicily, Greece, Turkey
Inside
$2,739
Oceanview
$2,909
Balcony
$3,679
Suite
$4,509
From
US$2,739
Per Person
View Trip
11 Day Treasures of the Western Mediterranean with Ponant
Cruise
 (2)

11 Days (10 Nights) Florence to Malaga
Cruise Line: Ponant
Ship: Le Boreal
Departure: 03 October 2027
Visit: Italy, Monaco, France, Spain
Inside
-
Oceanview
$6,990
Balcony
$7,350
Suite
$13,610
From
US$6,990
Per Person
View Trip
8 Day Mediterranean Holiday with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 06 October 2026
Visit: Spain, France, Italy, Corsica, Sardinia, Sicily
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$2,899
Oceanview
$3,199
Balcony
$4,299
Suite
$5,399
From
US$2,899
Save 2,899
Per Person
View Trip
15 Day Adriatic And Malta with Cunard
Cruise
 (13)

15 Days (14 Nights) Rome to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 30 July 2027
Visit: Italy, Malta, Croatia, Greece, Sicily
Cunard Fare
Value Fare
Inside
$2,929
Oceanview
$3,279
Balcony
$3,729
Suite
$8,199
From
US$2,929
Per Person
View Trip
15 Day Mediterranean And Adriatic with Cunard
Cruise
 (13)

15 Days (14 Nights) Rome to Trieste
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 14 July 2028
Visit: Italy, Spain, France, Corsica, Malta, Montenegro, Croatia
Cunard Fare
Value Fare
Inside
$2,969
Oceanview
$3,329
Balcony
$3,914
Suite
$7,379
From
US$2,969
Per Person
View Trip
11 Day Iberian Peninsula and Mediterranean jewels with Ponant
Cruise
 (2)

11 Days (10 Nights) Lisbon to Valletta
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 07 August 2027
Visit: Portugal, Spain, Sardinia, Italy, Sicily, Malta
Inside
-
Oceanview
-
Balcony
$8,140
Suite
$15,130
From
US$8,140
Per Person
View Trip
11 Day Coastal Mediterranean Gems with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Rome to Valletta
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 10 September 2026
Visit: Italy, France, Spain, Malta
Your World Inclusions
Exclusive Savings
Inside
$2,890
Oceanview
$3,315
Balcony
$4,717
Suite
$6,205
From
US$2,890
Save 3,908
Per Person
View Trip
8 Day Western Mediterranean with Cunard
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 10 August 2026
Visit: Italy, Spain, France
Inside
$1,959
Oceanview
$2,029
Balcony
$2,549
Suite
$4,419
From
US$1,959
Per Person
View Trip
11 Day Croissants & Cannoli with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 16 September 2027
Visit: Spain, France, Monaco, Italy, Corsica, Sardinia, Sicily
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$2,999
Oceanview
$3,349
Balcony
$5,149
Suite
$7,199
From
US$2,999
Save 2,999
Per Person
View Trip
20 Day Central Mediterranean with Cunard
Cruise
 (1)

20 Days (19 Nights) London to London
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 15 September 2028
Visit: England, Spain, Albania, Croatia, Greece, Italy, Malta
Cunard Fare
Value Fare
Inside
$4,339
Oceanview
$4,879
Balcony
$6,859
Suite
$14,509
From
US$4,339
Per Person
View Trip
15 Day Adriatic And Western Mediterranean with Cunard
Cruise
 (1)

15 Days (14 Nights) Rome to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 20 July 2026
Visit: Italy, France, Corsica, Spain, Sicily, Greece, Montenegro
Inside
$1,299
Oceanview
$1,399
Balcony
$1,699
Suite
$4,309
From
US$1,299
Per Person
View Trip
11 Day Italy Intensive Cruise: Amalfi, Siracusa & Venice with Azamara Cruises
Cruise
 (3)

11 Days (10 Nights) Rome to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 23 September 2028
Visit: Italy, Sicily, Montenegro, Croatia
Azamara Always Included
Inside
$2,559
Oceanview
$2,789
Balcony
$3,419
Suite
$4,809
From
US$2,559
Per Person
View Trip
15 Day An Extended Journey From Venetian Canals To Renaissance Island Marvels with Explora Journeys
Cruise
 (1)

15 Days (14 Nights) Venice to Venice
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 02 August 2027
Visit: Italy, Croatia, Montenegro, Greece, Turkey
Inside
-
Oceanview
-
Balcony
-
Suite
$9,280
From
US$9,280
Per Person
View Trip
8 Day Italy, Malta And Adriatic with Cunard
Cruise
 (13)

8 Days (7 Nights) Rome to Trieste
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 30 July 2027
Visit: Italy, Malta, Croatia
Cunard Fare
Value Fare
Inside
$1,569
Oceanview
$1,739
Balcony
$2,019
Suite
$4,329
From
US$1,569
Per Person
View Trip
8 Day Italy, France And Spain with Cunard
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 22 June 2026
Visit: Spain, Sardinia, Corsica, Sicily, Italy
Inside
$799
Oceanview
$899
Balcony
$1,199
Suite
$2,359
From
US$799
Per Person
View Trip
15 Day Italy, France And Spain with Cunard
Cruise
 (1)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 13 July 2026
Visit: Italy, France, Corsica, Spain
Inside
$1,809
Oceanview
$1,949
Balcony
$2,249
Suite
$4,749
From
US$1,809
Per Person
View Trip
20 Day Discover the Beauty of the Mediterranean with Emerald Cruises
New ReleaseCruise
 (3)

20 Days (19 Nights) Lisbon to Valletta
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 30 April 2027
Visit: Portugal, Spain, Morocco, Sardinia (+4 more), Corsica, Italy, Sicily, Malta
Inside
-
Oceanview
$20,290
Balcony
-
Suite
-
From
US$20,290
Per Person
View Trip
Results: 241-270 of 780

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