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Mediterranean Luxury Cruises

Explore the best luxury cruises sailing in and around the Mediterranean. Choose from 780 unique cruise itineraries with 1760 past traveler reviews from 10 leading cruise lines. September is the most popular month to join a luxury cruise sailing in and around the Mediterranean with 900 departures starting between May 2026 and April 2029.
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780 Cruises (900 Cruise Departures)
12 Day Spain & Italy Cruise: Barcelona, Salerno & Rome with Azamara Cruises
Cruise
 (8)

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 20 February 2027
Visit: Spain, Sardinia, Tunisia, Malta, Sicily, Italy
Azamara Always Included
Inside
$2,819
Oceanview
$3,289
Balcony
$3,769
Suite
$5,839
From
US$2,819
Per Person
View Trip
10 Day Romantic Locales & Canals with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Barcelona to Venice
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 21 June 2027
Visit: Spain, France, Italy, Sicily, Greece, Montenegro, Croatia
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$2,799
Oceanview
$3,049
Balcony
$4,699
Suite
$6,599
From
US$2,799
Save 2,799
Per Person
View Trip
25 Day Turkey, Egypt & Italy Combination Cruise: Ephesus, Alexandria & Amalfi Coast with Azamara Cruises
Cruise
 (3)

25 Days (24 Nights) Venice to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 10 November 2027
Visit: Italy, Greece, Cyprus, Turkey, Egypt, Sicily
Azamara Always Included
Inside
$9,439
Oceanview
$11,439
Balcony
$14,139
Suite
$20,639
From
US$9,439
Per Person
View Trip
8 Day Ancient Sites & Cities with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 05 November 2026
Visit: Italy, Sicily, Malta, Greece, Turkey
Memorial Day Sale
Your World Inclusions
Exclusive Savings
Inside
$2,000
Oceanview
$2,040
Balcony
$3,000
Suite
$3,920
From
US$2,000
Save 2,998
Per Person
View Trip
22 Day Mediterranean And Adriatic with Cunard
Cruise
 (13)

22 Days (21 Nights) Rome to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 11 August 2028
Visit: Italy, Malta, Montenegro, Croatia (+4 more), Greece, Sicily, Spain, France
Cunard Fare
Value Fare
Inside
$4,374
Oceanview
$4,869
Balcony
$5,859
Suite
$10,179
From
US$4,374
Per Person
View Trip
11 Day Enchanting Greece & the Amalfi Coast with Emerald Cruises
New ReleaseCruise
 (3)

11 Days (10 Nights) Athens to Rome
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 17 October 2026
Visit: Greece, Sicily, Malta, Italy
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$25,145
From
US$25,145
Save 1,800
Per Person
View Trip
15 Day Italy And Adriatic with Cunard
Cruise
 (1)

15 Days (14 Nights) Rome to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 29 June 2026
Visit: Italy, Sicily, Greece, Montenegro, Croatia, Malta
Cunard Fare
Inside
$2,169
Oceanview
$2,419
Balcony
-
Suite
-
From
US$2,169
Per Person
View Trip
8 Day Italy, France And Spain with Cunard
Cruise
 (13)

8 Days (7 Nights) Rome to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 02 July 2027
Visit: Italy, Spain, France, Corsica
Bonus Onboard Credit
Value Fare
Inside
$1,199
Oceanview
$1,299
Balcony
$1,439
Suite
$2,939
From
US$1,199
Per Person
View Trip
20 Day Rome, Ruins & Gondola Rides with Oceania Cruises
Cruise
 (1)

20 Days (19 Nights) Rome to Venice
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 19 July 2027
Visit: Italy, Sicily, Greece, Turkey, Albania, Montenegro, Croatia
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$5,899
Oceanview
$6,399
Balcony
$9,699
Suite
$13,599
From
US$5,899
Save 5,899
Per Person
View Trip
29 Day Mediterranean, Adriatic, Greece And Turkiye with Cunard
Cruise
 (13)

29 Days (28 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 26 May 2028
Visit: Italy, Sicily, Greece, Turkey (+4 more), Malta, Montenegro, Croatia, Spain
Cunard Fare
Value Fare
Inside
$5,929
Oceanview
$6,649
Balcony
$7,729
Suite
$14,659
From
US$5,929
Per Person
View Trip
16 Day An Extended Journey Of Historic Landmarks & Sun-kissed Islands with Explora Journeys
Cruise
 (1)

16 Days (15 Nights) Rome to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departures: Jul 2028 to Sep 2028
Visit: Italy, France, Corsica, Spain, Tunisia, Malta, Sicily
Inside
-
Oceanview
-
Balcony
-
Suite
$8,995
From
US$8,995
Per Person
View Trip
22 Day Mediterranean, Greek Islands And Adriatic with Cunard
Cruise
 (13)

22 Days (21 Nights) Istanbul to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 08 October 2027
Visit: Turkey, Greece, Sicily, Italy, Croatia, Spain
Value Fare
Inside
$4,179
Oceanview
$4,479
Balcony
$5,429
Suite
$12,329
From
US$4,179
Per Person
View Trip
12 Day Best Of The Mediterranean Cruise: Monte Carlo, Amalfi & Venice with Azamara Cruises
Cruise
 (3)

12 Days (11 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 24 April 2027
Visit: Spain, France, Monaco, Italy, Montenegro, Croatia, Slovenia
Azamara Always Included
Inside
$3,569
Oceanview
$3,579
Balcony
$4,549
Suite
$6,969
From
US$3,569
Per Person
View Trip
8 Day Spain Intensive Cruise: Cadiz, Malaga & Barcelona with Azamara Cruises
Cruise
 (5)

8 Days (7 Nights) Lisbon to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 14 April 2028
Visit: Portugal, Spain, Gibraltar
Azamara Always Included
Inside
$1,609
Oceanview
$1,749
Balcony
$2,149
Suite
$3,029
From
US$1,609
Per Person
View Trip
22 Day Italy, France, Spain And Adriatic with Cunard
Cruise
 (1)

22 Days (21 Nights) Rome to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 24 August 2026
Visit: Italy, Sicily, Greece, Montenegro (+4 more), Croatia, Malta, Spain, Corsica
Inside
-
Oceanview
$4,149
Balcony
-
Suite
-
From
US$4,149
Per Person
View Trip
8 Day Italy, France And Spain with Cunard
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 September 2026
Visit: Spain, Corsica, Sicily, Italy
Inside
$1,359
Oceanview
$1,409
Balcony
$1,779
Suite
-
From
US$1,359
Per Person
View Trip
15 Day Spain And Italy with Cunard
Cruise
 (6)

15 Days (14 Nights) London to London
Cruise Line: Cunard
Ship: Queen Mary 2
Departure: 31 March 2028
Visit: England, Spain, Italy, Sardinia
Value Fare
Inside
$3,039
Oceanview
$4,139
Balcony
$4,389
Suite
$9,539
From
US$3,039
Per Person
View Trip
12 Day Greece & Italy Cruise: Rhodes, Crete & Amalfi with Azamara Cruises
Cruise
 (8)

12 Days (11 Nights) Athens to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 26 July 2028
Visit: Greece, Turkey, Sicily, Italy
Azamara Always Included
Inside
$3,379
Oceanview
$3,659
Balcony
$4,519
Suite
$6,389
From
US$3,379
Per Person
View Trip
8 Day Italy, France & Spain Cruise: Rome, Nice & Barcelona with Azamara Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 04 March 2028
Visit: Italy, France, Spain
Azamara Always Included
Inside
$1,599
Oceanview
$2,009
Balcony
$2,609
Suite
$3,939
From
US$1,599
Per Person
View Trip
8 Day Italy & Greece Cruise: Amalfi Coast, Siracusa & Olympia with Azamara Cruises
Cruise
 (8)

8 Days (7 Nights) Rome to Athens
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 05 December 2026
Visit: Italy, Sicily, Greece
Azamara Always Included
Inside
$1,419
Oceanview
$1,359
Balcony
$1,589
Suite
$2,419
From
US$1,359
Per Person
View Trip
18 Day Mediterranean & Iberian New Year Cruise: Italy, Spain & Morocco with Azamara Cruises
Cruise
 (8)

18 Days (17 Nights) Rome to Lisbon
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 22 December 2026
Visit: Italy, Spain, Morocco, Portugal
Azamara Always Included
Inside
$3,659
Oceanview
$4,089
Balcony
$4,609
Suite
$7,629
From
US$3,659
Per Person
View Trip
15 Day Mediterranean And Adriatic with Cunard
Cruise
 (13)

15 Days (14 Nights) Trieste to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 08 September 2028
Visit: Italy, Croatia, Greece, Sicily, Spain, France, Corsica
Cunard Fare
Value Fare
Inside
$2,999
Oceanview
$3,494
Balcony
$4,304
Suite
$7,769
From
US$2,999
Per Person
View Trip
9 Day Spain And France with Cunard
Cruise
 (13)

9 Days (8 Nights) London to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 18 May 2028
Visit: England, Spain, Corsica, Italy
Cunard Fare
Value Fare
Inside
$1,529
Oceanview
$1,664
Balcony
$2,024
Suite
$3,599
From
US$1,529
Per Person
View Trip
12 Day A Journey From Ligurian Shores To The Cyclades' Dazzling Beauty with Explora Journeys
Cruise
 (1)

12 Days (11 Nights) Barcelona to Athens
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 14 March 2027
Visit: Spain, Italy, Sicily, Malta, Greece
Inside
-
Oceanview
-
Balcony
-
Suite
$6,335
From
US$6,335
Per Person
View Trip
13 Day Best Of The Mediterranean Cruise: Crete, Sicily, Corsica & Majorca with Azamara Cruises
Cruise
 (3)

13 Days (12 Nights) Athens to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 19 October 2027
Visit: Greece, Sicily, Malta, Tunisia (+4 more), Sardinia, France, Corsica, Spain
Azamara Always Included
Inside
$6,579
Oceanview
$7,229
Balcony
$8,689
Suite
-
From
US$6,579
Per Person
View Trip
18 Day Mediterranean & Egypt Combination Cruise: Salerno, Alexandria & Naples with Azamara Cruises
Cruise
 (8)

18 Days (17 Nights) Rome to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 05 December 2026
Visit: Italy, Sicily, Greece, Egypt, Malta
Azamara Always Included
Inside
$3,579
Oceanview
$3,879
Balcony
$4,469
Suite
$6,869
From
US$3,579
Per Person
View Trip
13 Day French & Italian Treasures with Oceania Cruises
Cruise
 (3)

13 Days (12 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 30 September 2026
Visit: Spain, France, Italy, Corsica, Sardinia, Sicily, Malta
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$3,899
Oceanview
$4,449
Balcony
$6,899
Suite
$8,699
From
US$3,899
Save 3,899
Per Person
View Trip
11 Day Ancient Indulgence with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Istanbul to Trieste
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 28 October 2027
Visit: Turkey, Greece, Montenegro, Croatia, Slovenia, Italy
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$3,199
Oceanview
$4,099
Balcony
$4,699
Suite
$6,699
From
US$3,199
Save 3,199
Per Person
View Trip
22 Day Mediterranean, Adriatic And Greece with Cunard
Cruise
 (13)

22 Days (21 Nights) Istanbul to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 21 May 2027
Visit: Turkey, Greece, Sicily, Italy (+4 more), Malta, Montenegro, Croatia, Spain
Bonus Onboard Credit
Value Fare
Inside
$3,439
Oceanview
$3,789
Balcony
$4,479
Suite
$8,809
From
US$3,439
Per Person
View Trip
15 Day Spain & Portugal Cruise: Valencia, Seville & Lisbon with Azamara Cruises
Cruise
 (3)

15 Days (14 Nights) Barcelona to Lisbon
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 11 March 2028
Visit: Spain, Gibraltar, Portugal
Azamara Always Included
Inside
$3,639
Oceanview
$4,269
Balcony
$5,459
Suite
$8,119
From
US$3,639
Per Person
View Trip
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