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Mediterranean Luxury Cruises

Explore the best luxury cruises sailing in and around the Mediterranean. Choose from 780 unique cruise itineraries with 1760 past traveler reviews from 10 leading cruise lines. September is the most popular month to join a luxury cruise sailing in and around the Mediterranean with 900 departures starting between May 2026 and April 2029.
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780 Cruises (900 Cruise Departures)
13 Day Mediterranean Nights with Regent Seven Seas
Cruise

13 Days (12 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 28 September 2026
Visit: Spain, France, Italy, Malta
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,799
Suite
$14,449
From
US$13,799
Save 13,799
Per Person
View Trip
11 Day A Journey Of Coastal Elegance & Cultural Contrasts with Explora Journeys
Cruise

11 Days (10 Nights) Barcelona to Barcelona
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 29 October 2027
Visit: Spain, Portugal, Morocco
Inside
-
Oceanview
-
Balcony
-
Suite
$6,560
From
US$6,560
Per Person
View Trip
10 Day Toast To Toulon with Regent Seven Seas
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 31 August 2027
Visit: Spain, France, Italy, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,399
Suite
$10,799
From
US$10,399
Save 10,399
Per Person
View Trip
10 Day Iconic Art & Architecture with Oceania Cruises
Cruise

10 Days (9 Nights) Rome to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 31 January 2028
Visit: Italy, Sardinia, Spain, Tunisia, Sicily, Malta
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,249
Suite
$5,099
From
US$3,249
Save 3,249
Per Person
View Trip
22 Day French Yacht Harbors, Montenegro, Italy & Greece with Seabourn
Cruise

22 Days (21 Nights) Barcelona to Athens
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departures: Apr 2028 to Aug 2028
Visit: Spain, France, Corsica, Sardinia (+6 more), Italy, Sicily, Malta, Montenegro, Croatia, Greece
Inside
-
Oceanview
-
Balcony
$13,679
Suite
$22,949
From
US$13,679
Per Person
View Trip
8 Day Mediterranean Wonders: French & Italian Rivieras with Scenic
New ReleaseCruise

8 Days (7 Nights) Nice to Rome
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 31 May 2026
Visit: France, Italy, Corsica, Sardinia
Inside
-
Oceanview
-
Balcony
$9,995
Suite
$26,410
From
US$9,995
Per Person
View Trip
11 Day Seville, Granada, Murcia And French Riviera with Seabourn
Cruise

11 Days (10 Nights) Lisbon to Genoa
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 08 April 2027
Visit: Portugal, Spain, France, Corsica, Italy
Inside
-
Oceanview
-
Balcony
$5,099
Suite
$9,009
From
US$5,099
Per Person
View Trip
29 Day Mediterranean Yacht Harbors & Evening At Ephesus with Seabourn
Cruise

29 Days (28 Nights) Monte Carlo to Athens
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 17 June 2028
Visit: Monaco, Italy, Sicily, Malta (+4 more), Montenegro, Croatia, Greece, Turkey
Inside
-
Oceanview
-
Balcony
$18,809
Suite
$30,149
From
US$18,809
Per Person
View Trip
9 Day Nice to Nice with Silversea
Cruise

9 Days (8 Nights) Nice to Nice
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 24 May 2027
Visit: France, Sardinia, Corsica, Italy
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
$5,800
Balcony
$6,400
Suite
$8,900
From
US$5,800
Save 2,000
Per Person
View Trip
8 Day Spotlight On Sparkling Wines with Regent Seven Seas
Cruise

8 Days (7 Nights) Rome to Venice
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 10 October 2026
Visit: Italy, Sicily, Malta, Croatia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,949
Suite
$11,349
From
US$10,949
Save 10,949
Per Person
View Trip
19 Day Sailing Into Spring with Oceania Cruises
Cruise

19 Days (18 Nights) Athens to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 18 March 2028
Visit: Greece, Montenegro, Croatia, Malta (+6 more), Sicily, Italy, Sardinia, Monaco, France, Spain
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,849
Suite
$11,799
From
US$6,849
Save 6,849
Per Person
View Trip
13 Day Nice to Fusina (Venice) with Silversea
Cruise

13 Days (12 Nights) Nice to Venice
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 25 April 2027
Visit: France, Italy, Albania, Montenegro, Croatia, Slovenia
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
$8,500
Balcony
$10,000
Suite
$14,600
From
US$8,500
Save 1,500
Per Person
View Trip
8 Day Barcelona to Rome with Silversea
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Dawn
Departure: 01 November 2026
Visit: Spain, Sardinia, Tunisia, Sicily, Italy
All-Inclusive Plus Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
$4,700
Balcony
$5,100
Suite
$9,900
From
US$4,700
Save 2,000
Per Person
View Trip
21 Day Ode On A Grecian Journey with Oceania Cruises
Cruise

21 Days (20 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 17 July 2027
Visit: Italy, Sicily, Malta, Greece, Montenegro, Croatia, Spain
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,099
Suite
$14,699
From
US$9,099
Save 9,099
Per Person
View Trip
8 Day Malta, Italy & Spain with Seabourn
Cruise

8 Days (7 Nights) Athens to Barcelona
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 30 October 2027
Visit: Greece, Malta, Sicily, Sardinia, Spain
Inside
-
Oceanview
-
Balcony
$5,524
Suite
$8,499
From
US$5,524
Per Person
View Trip
8 Day Majestic Mediterranean with Regent Seven Seas
Cruise

8 Days (7 Nights) Athens to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 01 November 2026
Visit: Greece, Malta, Sicily, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,499
Suite
$10,449
From
US$9,499
Save 9,499
Per Person
View Trip
8 Day European Yearnings with Oceania Cruises
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 02 July 2027
Visit: Italy, Monaco, France, Spain
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,199
Suite
$5,199
From
US$3,199
Save 3,199
Per Person
View Trip
9 Day Catalonia to Andalusia with Emerald Cruises
New ReleaseCruise

9 Days (8 Nights) Barcelona to Malaga
Cruise Line: Emerald Cruises
Ship: Emerald Sakara
Departure: 23 October 2027
Visit: Spain, Gibraltar, Morocco
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$7,891
From
US$7,891
Save 1,884
Per Person
View Trip
22 Day A Grand Journey Through Storied Streets, Legendary Landmarks & Sunlit Vistas with Explora Journeys
Cruise

22 Days (21 Nights) Barcelona to Jeddah
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 08 November 2027
Visit: Spain, Malta, Greece, Cyprus, Egypt, Saudi Arabia, Jordan
Inside
-
Oceanview
-
Balcony
-
Suite
$10,575
From
US$10,575
Per Person
View Trip
15 Day French Yacht Harbors, Southern France & Corsica with Seabourn
Cruise

15 Days (14 Nights) Rome to Monte Carlo
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 03 June 2028
Visit: Italy, France, Spain, Sardinia, Corsica, Monaco
Inside
-
Oceanview
-
Balcony
$10,799
Suite
$16,469
From
US$10,799
Per Person
View Trip
10 Day Mediterranean Masterpieces with Oceania Cruises
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 28 February 2028
Visit: Italy, Sicily, Sardinia, Corsica, France, Spain
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,549
Suite
$5,299
From
US$3,549
Save 3,549
Per Person
View Trip
15 Day A Holiday To Remember with Oceania Cruises
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 20 December 2027
Visit: Spain, Morocco, Tunisia, Sicily, Italy
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,299
Suite
$8,499
From
US$6,299
Save 6,299
Per Person
View Trip
11 Day Yachting Sicily to Elba via the Amalfi Coast with Emerald Cruises
New ReleaseCruise

11 Days (10 Nights) Valletta to Rome
Cruise Line: Emerald Cruises
Ship: Emerald Sakara
Departure: 30 June 2027
Visit: Italy, Sicily, Malta
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
$8,247
Balcony
-
Suite
$11,037
From
US$8,247
Save 1,898
Per Person
View Trip
12 Day Rome to Barcelona with Silversea
Cruise

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Ray
Departure: 18 October 2026
Visit: Italy, Sicily, Malta, Tunisia, Sardinia, Spain
Last Minute Fare
All-Inclusive Plus Fare
Inside
-
Oceanview
-
Balcony
$6,350
Suite
$12,000
From
US$6,350
Per Person
View Trip
10 Day Lisbon to Nice with Silversea
Cruise

10 Days (9 Nights) Lisbon to Nice
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 23 March 2027
Visit: Portugal, Spain, France
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
$5,800
Balcony
$6,400
Suite
$9,600
From
US$5,800
Save 3,000
Per Person
View Trip
15 Day French Yacht Harbors, Southern France, Spain & Italy with Seabourn
Cruise

15 Days (14 Nights) Rome to Rome
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 29 July 2028
Visit: Italy, France, Spain, Corsica, Sardinia
Inside
-
Oceanview
-
Balcony
$9,449
Suite
$15,119
From
US$9,449
Per Person
View Trip
16 Day Athens to Lisbon with Silversea
Cruise

16 Days (15 Nights) Athens to Lisbon
Cruise Line: Silversea
Ship: Silver Spirit
Departure: 07 November 2026
Visit: Greece, Malta, Sicily, Tunisia, Sardinia, Spain, Portugal
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
$8,400
Balcony
$9,400
Suite
$8,700
From
US$8,400
Save 4,000
Per Person
View Trip
8 Day Exploring Montenegro, Malta & Sicily with Seabourn
Cruise

8 Days (7 Nights) Dubrovnik to Rome
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 23 September 2028
Visit: Croatia, Montenegro, Malta, Sicily, Italy
Inside
-
Oceanview
-
Balcony
$5,669
Suite
$8,999
From
US$5,669
Per Person
View Trip
19 Day Myth & Marble with Regent Seven Seas
Cruise

19 Days (18 Nights) Rome to Athens
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 02 September 2027
Visit: Italy, Sicily, Malta, Montenegro, Croatia, Greece
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$21,749
Suite
$22,699
From
US$21,749
Save 21,749
Per Person
View Trip
11 Day Civitavecchia (Rome) to Lisbon with Silversea
Cruise

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Spirit
Departure: 22 November 2027
Visit: Italy, Spain, Morocco, Portugal
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
$5,000
Balcony
$5,600
Suite
$5,200
From
US$5,000
Save 2,000
Per Person
View Trip
Results: 451-480 of 780

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