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All South America Tour & Cruise Packages

Compare 42 tour and cruise packages to South America. Guided land journeys combined seamlessly with cruises exploring the islands of the Galapagos, the Amazon and Antarctica. Travel with the world's leading South American specialists and expedition cruise lines.
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37 Days
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42 Packages (277 Package Departures)
30 Day Ultimate South America with Brazil's Amazon & Galapagos Cruise with Cosmos
Tour + Cruise
 (3)

30 Days Manaus to Guayaquil
Operated By: Cosmos
Departures: Jun 2026 to Oct 2027
Visit: Brazil, Argentina, Peru, Ecuador, Galapagos
Black Friday Sale
Exclusive Savings
From
US$9,416
Save 351
Per Person
View Trip
33 Day Highlights of South America and Chilean Fjords Cruise with Travelmarvel
Tour + Cruise
 (1)

33 Days Santiago to Lima
Operated By: Travelmarvel
Departure: 21 February 2027
Trip Styles: Coach, Cruise, Scenic
Visit: Chile, Argentina, Falkland Islands, Uruguay, Brazil, Peru
Exclusive Savings
Inside
-
Oceanview
$13,572
Balcony
$14,836
Suite
-
From
US$13,572
Save 223
Per Person
View Trip
26 Day Ultimate South America with Galapagos Cruise with Cosmos
Tour + Cruise
 (1)

26 Days Rio de Janeiro to Guayaquil
Operated By: Cosmos
Departures: Jul 2026 to Nov 2027
Visit: Brazil, Argentina, Peru, Ecuador, Galapagos
Exclusive Savings
From
US$9,872
Save 540
Per Person
View Trip
13 Day Highlights of Peru with Galápagos Legend East Cruise with Trafalgar
Tour + Cruise

13 Days Lima to Quito
Operated By: Trafalgar
Departures: Aug 2026 to Nov 2026
Visit: Peru, Ecuador, Galapagos
Sign Up Savings
Today's Deal
Exclusive Savings
From
US$7,124
Save 351
Per Person
View Trip
35 Day Antarctic Voyage with South American Discovery & Amazon Cruise with APT
New ReleaseTour + Cruise

35 Days Lima to Rio de Janeiro
Operated By: APT
Ships: Seabourn Venture, Delfin III
Departure: 25 January 2027
Trip Styles: Cruise, Wildlife, Scenic
Visit: Peru, Argentina, Antarctica, Brazil
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$32,864
Suite
$35,412
From
US$32,864
Save 581
Per Person
View Trip
20 Day Wonders of Patagonia and Antarctica - Cruise & Land Journey with Scenic
Tour + Cruise

20 Days Santiago to Buenos Aires
Operated By: Scenic
Ships: Scenic Eclipse II, Scenic Eclipse I
Departures: Jan 2027 to Feb 2027
Trip Styles: Coach, Cruise, Scenic
Visit: Chile, Argentina, Antarctica
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$60,815
Suite
$72,019
From
US$60,815
Save 1,790
Per Person
View Trip
17 Day Mysteries of the Inca Empire with Galapagos Cruise with Cosmos
Tour + Cruise

17 Days Lima to Quito
Operated By: Cosmos
Departures: Oct 2026 to Nov 2027
Visit: Peru, Ecuador, Galapagos
Exclusive Savings
From
US$6,861
Save 315
Per Person
View Trip
21 Day Mysteries of the Inca Empire with Peru's Amazon & Galapagos Cruise with Cosmos
Tour + Cruise

21 Days Lima to Quito
Operated By: Cosmos
Departures: Nov 2026 to Oct 2027
Visit: Peru, Ecuador, Galapagos
Exclusive Savings
From
US$8,310
Save 284
Per Person
View Trip
37 Day Antarctic Voyage with South America and Galápagos Islands with APT
New ReleaseTour + Cruise

37 Days Guayaquil to Rio de Janeiro
Operated By: APT
Ship: Seabourn Venture
Departure: 23 January 2027
Trip Styles: Cruise, Wildlife, Scenic
Visit: Ecuador, Galapagos, Peru, Argentina, Antarctica, Brazil
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$42,039
Suite
$44,587
From
US$42,039
Save 756
Per Person
View Trip
13 Day Peru Splendors with Galapagos Cruise with Globus
Tour + Cruise

13 Days Lima to Guayaquil
Operated By: Globus
Departures: Jul 2026 to Nov 2027
Visit: Peru, Ecuador, Galapagos
Exclusive Savings
From
US$7,000
Save 376
Per Person
View Trip
37 Day Machu Picchu, Amazon & Antarctic Odyssey - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

37 Days Lima to Buenos Aires
Operated By: Scenic
Ship: Scenic Eclipse II
Departure: 26 October 2026
Trip Styles: Coach, Cruise, Wildlife, Scenic
Visit: Peru, Argentina, Falkland Islands, South Georgia Island, Antarctica
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$79,865
Suite
$101,253
From
US$79,865
Save 2,340
Per Person
View Trip
18 Day Land of the Incas with Galápagos Legend East Cruise with Trafalgar
Tour + Cruise

18 Days Lima to Quito
Operated By: Trafalgar
Departures: Oct 2026 to Dec 2026
Visit: Peru, Ecuador, Galapagos
Today's Deal
Exclusive Savings
From
US$9,192
Save 639
Per Person
View Trip
9 Day Cruising the Galapagos Islands with Tauck
Tour + Cruise

9 Days Guayaquil to Guayaquil
Operated By: Tauck
Departures: Jan 2027 to Dec 2027
Visit: Ecuador, Galapagos
From
US$9,490
Per Person
View Trip
23 Day South American Discovery with Galápagos Cruise with Globus
Tour + Cruise

23 Days Rio de Janeiro to Guayaquil
Operated By: Globus
Departures: Oct 2026 to Oct 2027
Visit: Brazil, Argentina, Peru, Ecuador, Galapagos
Exclusive Savings
From
US$12,099
Save 647
Per Person
View Trip
19 Day Legacy of the Incas with Galapagos Cruise with Globus
Tour + Cruise

19 Days Lima to Guayaquil
Operated By: Globus
Departure: 22 September 2026
Visit: Peru, Ecuador, Galapagos
Exclusive Savings
From
US$11,035
Save 375
Per Person
View Trip
22 Day Treasures of South America with Chilean Fjords - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

22 Days Santiago to Rio de Janeiro
Operated By: Scenic
Ship: Scenic Eclipse I
Departure: 04 November 2026
Trip Styles: Coach, Cruise, Scenic
Visit: Chile, Argentina, Brazil
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$44,468
Suite
-
From
US$44,468
Save 1,287
Per Person
View Trip
13 Day Antarctica with Tauck
Tour + Cruise

13 Days Buenos Aires to Buenos Aires
Operated By: Tauck
Ship: Le Boréal
Departures: Jan 2027 to Feb 2027
Trip Styles: Coach, Cruise, Scenic
Visit: Argentina, Antarctica
From
US$14,490
Per Person
View Trip
21 Day South America Revealed with Galápagos Legend East Cruise with Trafalgar
Tour + Cruise

21 Days Rio de Janeiro to Quito
Operated By: Trafalgar
Departures: Aug 2026 to Nov 2026
Visit: Brazil, Argentina, Peru, Ecuador, Galapagos
Sign Up Savings
Today's Deal
Exclusive Savings
From
US$10,993
Save 857
Per Person
View Trip
18 Day Antarctic Voyage with Chile with APT
Tour + Cruise

18 Days Santiago to Buenos Aires
Operated By: APT
Ship: Seabourn Venture
Departure: 06 February 2027
Trip Styles: Cruise, Scenic
Visit: Chile, Argentina, Antarctica
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$19,045
Suite
$21,593
From
US$19,045
Save 350
Per Person
View Trip
20 Day Antarctic Voyage with Brazil Highlights with APT
Tour + Cruise

20 Days Buenos Aires to Rio de Janeiro
Operated By: APT
Ship: Seabourn Venture
Departure: 09 February 2027
Trip Styles: Cruise, Scenic
Visit: Argentina, Antarctica, Brazil
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$21,601
Suite
$24,149
From
US$21,601
Save 394
Per Person
View Trip
21 Day South America Revealed with Galápagos Legend North and Central Cruise with Trafalgar
Tour + Cruise

21 Days Rio de Janeiro to Quito
Operated By: Trafalgar
Departures: Aug 2026 to Nov 2026
Visit: Brazil, Argentina, Peru, Ecuador, Galapagos
Sign Up Savings
Today's Deal
Exclusive Savings
From
US$10,993
Save 857
Per Person
View Trip
26 Day Peru, Amazon & the Chilean Fjords Expedition - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

26 Days Lima to Buenos Aires
Operated By: Scenic
Ship: Scenic Eclipse I
Departure: 22 October 2026
Trip Styles: Coach, Cruise, Wildlife, Scenic
Visit: Peru, Chile, Argentina
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$49,341
Suite
-
From
US$49,341
Save 1,414
Per Person
View Trip
8 Day Galapagos: Wildlife Wonderland with Tauck
Tour + Cruise

8 Days Quito to Guayaquil
Operated By: Tauck
Departure: 21 July 2026
Visit: Ecuador, Galapagos
From
US$6,690
Per Person
View Trip
14 Day Patagonia: Edge of the World with Collette
Tour + Cruise

14 Days Buenos Aires to Buenos Aires
Operated By: Collette
Departures: Oct 2026 to Mar 2027
Visit: Argentina, Chile
Exclusive Savings
From
US$10,010
Save 209
Per Person
View Trip
15 Day Highlights of Ecuador & the Galapagos with Exodus Tours
New ReleaseTour + Cruise

15 Days Quito to Quito
Operated By: Exodus Tours
Departures: May 2026 to Dec 2027
Visit: Ecuador, Galapagos
Sign Up Savings
Exclusive Savings
From
US$5,689
Save 1,209
Per Person
View Trip
34 Day Highlights of South America and Chilean Fjords Cruise with Travelmarvel
Tour + Cruise

34 Days Rio de Janeiro to Lima
Operated By: Travelmarvel
Departure: 02 March 2027
Trip Styles: Coach, Cruise, Scenic
Visit: Brazil, Argentina, Uruguay, Falkland Islands, Chile, Peru
Exclusive Savings
Inside
-
Oceanview
$14,059
Balcony
$15,324
Suite
-
From
US$14,059
Save 236
Per Person
View Trip
29 Day Ultimate Journey: Patagonia, Argentina, Brazil & Antarctica - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

29 Days Santiago to Rio de Janeiro
Operated By: Scenic
Ships: Scenic Eclipse I
Departures: Jan 2027 to Feb 2028
Trip Styles: Coach, Cruise, Scenic
Visit: Chile, Argentina, Antarctica, Brazil
Preferred Plus Fare + Air Credit
Select Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$46,990
Suite
$54,337
From
US$46,990
Save 6,068
Per Person
View Trip
23 Day Antarctic Voyage with Chile and Brazil Highlights with APT
New ReleaseTour + Cruise

23 Days Santiago to Rio de Janeiro
Operated By: APT
Ship: Seabourn Venture
Departure: 06 February 2027
Trip Styles: Cruise, Scenic
Visit: Chile, Argentina, Antarctica, Brazil
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$23,373
Suite
$25,921
From
US$23,373
Save 422
Per Person
View Trip
17 Day Peru Splendors with Peru's Amazon & Galapagos Cruise with Globus
Tour + Cruise

17 Days Lima to Guayaquil
Operated By: Globus
Departures: Jul 2026 to Nov 2027
Visit: Peru, Ecuador, Galapagos
Exclusive Savings
From
US$8,369
Save 298
Per Person
View Trip
15 Day Peru & the Galapagos Islands with Tauck
Tour + Cruise

15 Days Lima to Guayaquil
Operated By: Tauck
Departures: Mar 2026 to Oct 2027
Visit: Peru, Ecuador, Galapagos
From
US$14,690
Per Person
View Trip
Results: 1-30 of 42

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