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All South America Tour & Cruise Packages

Compare 44 tour and cruise packages to South America. Guided land journeys combined seamlessly with cruises exploring the islands of the Galapagos, the Amazon and Antarctica. Travel with the world's leading South American specialists and expedition cruise lines.
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37 Days
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44 Packages (301 Package Departures)
30 Day Ultimate South America with Brazil's Amazon & Galapagos Cruise with Cosmos
Tour + Cruise
 (3)

30 Days Manaus to Guayaquil
Operated By: Cosmos
Departures: May 2026 to Nov 2027
Visit: Brazil, Argentina, Peru, Ecuador, Galapagos
Exclusive Savings
From
US$9,416
Save 351
Per Person
View Trip
33 Day Highlights of South America and Chilean Fjords Cruise with Travelmarvel
Tour + Cruise
 (1)

33 Days Santiago to Lima
Operated By: Travelmarvel
Departure: 21 February 2027
Trip Styles: Coach, Cruise, Scenic
Visit: Chile, Argentina, Falkland Islands, Uruguay, Brazil, Peru
Exclusive Savings
Inside
-
Oceanview
$13,572
Balcony
$14,836
Suite
-
From
US$13,572
Save 223
Per Person
View Trip
26 Day Ultimate South America with Galapagos Cruise with Cosmos
Tour + Cruise
 (1)

26 Days Rio de Janeiro to Guayaquil
Operated By: Cosmos
Departures: May 2026 to Nov 2027
Visit: Brazil, Argentina, Peru, Ecuador, Galapagos
Black Friday Sale
Exclusive Savings
From
US$9,872
Save 540
Per Person
View Trip
21 Day Highlights of Antarctica, Argentina and Brazil - Cruise & Land Journey with Scenic
Tour + Cruise

21 Days Rio de Janeiro to Buenos Aires
Operated By: Scenic
Ships: Scenic Eclipse II, Scenic Eclipse I
Departures: Jan 2027 to Jan 2027
Trip Styles: Coach, Cruise, Scenic
Visit: Brazil, Argentina, Antarctica
Multiple Deals Available
Inside
-
Oceanview
-
Balcony
$27,400
Suite
$34,440
From
US$27,400
Save 26,615
Per Person
View Trip
29 Day Ultimate Journey: Patagonia, Argentina, Brazil & Antarctica - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

29 Days Santiago to Rio de Janeiro
Operated By: Scenic
Ship: Scenic Eclipse I
Departure: 30 January 2027
Trip Styles: Coach, Cruise, Scenic
Visit: Chile, Argentina, Antarctica, Brazil
Fly Free Premium Economy
Fly Free Business Class
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$45,565
Suite
$51,167
From
US$45,565
Save 23,805
Per Person
View Trip
15 Day Highlights of Ecuador & the Galapagos with Exodus Tours
New ReleaseTour + Cruise

15 Days Quito to Quito
Operated By: Exodus Tours
Departures: Feb 2026 to Dec 2027
Visit: Ecuador, Galapagos
Sign Up Savings
Exclusive Savings
From
US$5,354
Save 1,544
Per Person
View Trip
34 Day Highlights of South America and Chilean Fjords Cruise with Travelmarvel
Tour + Cruise

34 Days Rio de Janeiro to Lima
Operated By: Travelmarvel
Departure: 02 March 2027
Trip Styles: Coach, Cruise, Scenic
Visit: Brazil, Argentina, Uruguay, Falkland Islands, Chile, Peru
Exclusive Savings
Inside
-
Oceanview
$14,059
Balcony
$15,324
Suite
-
From
US$14,059
Save 236
Per Person
View Trip
22 Day Treasures of South America with Chilean Fjords - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

22 Days Santiago to Rio de Janeiro
Operated By: Scenic
Ship: Scenic Eclipse I
Departure: 04 November 2026
Trip Styles: Coach, Cruise, Scenic
Visit: Chile, Argentina, Brazil
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$23,044
Suite
-
From
US$23,044
Save 22,711
Per Person
View Trip
35 Day Antarctic Voyage with South American Discovery & Amazon Cruise with APT
New ReleaseTour + Cruise

35 Days Lima to Rio de Janeiro
Operated By: APT
Ships: Seabourn Venture, Delfin III
Departure: 25 January 2027
Trip Styles: Cruise, Wildlife, Scenic
Visit: Peru, Argentina, Antarctica, Brazil
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$32,864
Suite
$35,412
From
US$32,864
Save 581
Per Person
View Trip
19 Day Legacy of the Incas with Galapagos Cruise with Globus
Tour + Cruise

19 Days Lima to Guayaquil
Operated By: Globus
Departures: Jun 2026 to Sep 2026
Visit: Peru, Ecuador, Galapagos
Exclusive Savings
From
US$11,035
Save 386
Per Person
View Trip
17 Day Peru Splendors with Peru's Amazon & Galapagos Cruise with Globus
Tour + Cruise

17 Days Lima to Guayaquil
Operated By: Globus
Departures: May 2026 to Nov 2027
Visit: Peru, Ecuador, Galapagos
Exclusive Savings
From
US$8,369
Save 298
Per Person
View Trip
7 Day Independent Galapagos Cruise Aboard the Galapagos Legend with Globus
New ReleaseTour + Cruise

7 Days Quito to Guayaquil
Operated By: Globus
Departures: Mar 2026 to Mar 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$5,000
Save 219
Per Person
View Trip
29 Day Antarctic Voyage with South American Discovery with APT
Tour + Cruise

29 Days Lima to Rio de Janeiro
Operated By: APT
Ship: Seabourn Venture
Departure: 31 January 2027
Trip Styles: Cruise, Scenic
Visit: Peru, Argentina, Antarctica, Brazil
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$26,524
Suite
$29,072
From
US$26,524
Save 471
Per Person
View Trip
21 Day Mysteries of the Inca Empire with Peru's Amazon & Galapagos Cruise with Cosmos
Tour + Cruise

21 Days Lima to Quito
Operated By: Cosmos
Departures: Nov 2026 to Oct 2027
Visit: Peru, Ecuador, Galapagos
Exclusive Savings
From
US$8,310
Save 284
Per Person
View Trip
30 Day Antarctic Voyage with Peru and Amazon Cruise with APT
New ReleaseTour + Cruise

30 Days Lima to Buenos Aires
Operated By: APT
Ships: Seabourn Venture, Delfin III
Departure: 25 January 2027
Trip Styles: Cruise, Wildlife, Scenic
Visit: Peru, Argentina, Antarctica
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$27,999
Suite
$30,547
From
US$27,999
Save 496
Per Person
View Trip
11 Day Independent Galapagos Cruise Aboard the Galápagos Legend with Ecuador's Amazon with Globus
New ReleaseTour + Cruise

11 Days Quito to Guayaquil
Operated By: Globus
Departures: Mar 2026 to Mar 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$7,265
Save 322
Per Person
View Trip
18 Day Antarctic Voyage with Chile with APT
Tour + Cruise

18 Days Santiago to Buenos Aires
Operated By: APT
Ship: Seabourn Venture
Departure: 06 February 2027
Trip Styles: Cruise, Scenic
Visit: Chile, Argentina, Antarctica
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$19,045
Suite
$21,593
From
US$19,045
Save 350
Per Person
View Trip
7 Day Ecuador and Galápagos Islands Cruise with APT
New ReleaseTour + Cruise

7 Days Guayaquil to Guayaquil
Operated By: APT
Departure: 26 August 2026
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$14,697
Save 298
Per Person
View Trip
13 Day Peru Splendors with Galapagos Cruise with Globus
Tour + Cruise

13 Days Lima to Guayaquil
Operated By: Globus
Departures: May 2026 to Nov 2027
Visit: Peru, Ecuador, Galapagos
Exclusive Savings
From
US$7,000
Save 376
Per Person
View Trip
17 Day Mysteries of the Inca Empire with Galapagos Cruise with Cosmos
Tour + Cruise

17 Days Lima to Quito
Operated By: Cosmos
Departures: Dec 2026 to Nov 2027
Visit: Peru, Ecuador, Galapagos
Exclusive Savings
From
US$6,957
Save 241
Per Person
View Trip
32 Day Antarctic Voyage with Galápagos and Peru with APT
New ReleaseTour + Cruise

32 Days Guayaquil to Buenos Aires
Operated By: APT
Ship: Seabourn Venture
Departure: 23 January 2027
Trip Styles: Cruise, Wildlife, Scenic
Visit: Ecuador, Galapagos, Peru, Argentina, Antarctica
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$37,123
Suite
$39,671
From
US$37,123
Save 672
Per Person
View Trip
14 Day Patagonia: Edge of the World with Collette
Tour + Cruise

14 Days Buenos Aires to Buenos Aires
Operated By: Collette
Departures: Feb 2026 to Mar 2027
Visit: Argentina, Chile
Exclusive Savings
From
US$9,814
Save 885
Per Person
View Trip
8 Day Galapagos: Wildlife Wonderland with Tauck
Tour + Cruise

8 Days Quito to Guayaquil
Operated By: Tauck
Departures: Mar 2026 to Dec 2026
Visit: Ecuador, Galapagos
From
US$6,690
Per Person
View Trip
14 Day Peru & Galapagos by Yacht with Collette
Tour + Cruise

14 Days Lima to Quito
Operated By: Collette
Departures: Feb 2026 to May 2027
Visit: Peru, Ecuador, Galapagos
Exclusive Savings
From
US$9,441
Save 166
Per Person
View Trip
11 Day Antarctica: The White Continent with Collette
Tour + Cruise

11 Days Buenos Aires to Buenos Aires
Operated By: Collette
Departures: Feb 2026 to Mar 2027
Visit: Chile, Argentina, Antarctica
Exclusive Savings
From
US$9,250
Save 196
Per Person
View Trip
15 Day Peru & the Galapagos Islands with Tauck
Tour + Cruise

15 Days Lima to Guayaquil
Operated By: Tauck
Departures: Mar 2027 to Oct 2027
Visit: Peru, Ecuador, Galapagos
From
US$14,790
Per Person
View Trip
21 Day South America Revealed with Galápagos Legend East Cruise with Trafalgar
Tour + Cruise

21 Days Rio de Janeiro to Quito
Operated By: Trafalgar
Departures: Jun 2026 to Nov 2026
Visit: Brazil, Argentina, Peru, Ecuador, Galapagos
Sign Up Savings
Exclusive Savings
From
US$11,454
Save 396
Per Person
View Trip
23 Day Antarctic Voyage with Chile and Brazil Highlights with APT
New ReleaseTour + Cruise

23 Days Santiago to Rio de Janeiro
Operated By: APT
Ship: Seabourn Venture
Departure: 06 February 2027
Trip Styles: Cruise, Scenic
Visit: Chile, Argentina, Antarctica, Brazil
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$23,373
Suite
$25,921
From
US$23,373
Save 422
Per Person
View Trip
21 Day South America Revealed with Galápagos Legend North and Central Cruise with Trafalgar
Tour + Cruise

21 Days Rio de Janeiro to Quito
Operated By: Trafalgar
Departures: Jun 2026 to Nov 2026
Visit: Brazil, Argentina, Peru, Ecuador, Galapagos
Sign Up Savings
Exclusive Savings
From
US$11,454
Save 396
Per Person
View Trip
18 Day Land of the Incas with Galápagos Legend North and Central Cruise with Trafalgar
Tour + Cruise

18 Days Lima to Quito
Operated By: Trafalgar
Departures: May 2026 to Nov 2026
Visit: Peru, Ecuador, Galapagos
Sign Up Savings
Exclusive Savings
From
US$9,499
Save 332
Per Person
View Trip
Results: 1-30 of 44

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