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Mekong River Cruises Starting In April 2027 and 2028

Are you planning a river cruise along the Mekong in April 2027 or 2028? Choose from 44 unique river cruises with 738 departures operated by Mekong's leading river cruise lines. Easily compare prices, itineraries, inclusions and traveler reviews to find the Mekong river cruise that best matches your travel style, budget and dates.
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44 River Cruises (738 River Cruise Departures)
8 Day Mekong Discovery (Northbound) with Avalon River Cruises
River Cruise
 (2)

8 Days Ho Chi Minh City to Phnom Penh
Cruise Line: Avalon River Cruises
Ship: Avalon Saigon
Departures: Aug 2026 to Nov 2027
Rivers: Mekong
Visit: Vietnam, Cambodia
Exclusive Savings
Inside
-
River View
-
Balcony
-
Suite
$3,309
From
US$3,309
Save 2,000
Per Person
View Trip
8 Day Mekong Discovery (Southbound) with Avalon River Cruises
River Cruise
 (2)

8 Days Phnom Penh to Ho Chi Minh City
Cruise Line: Avalon River Cruises
Ship: Avalon Saigon
Departures: Apr 2026 to Dec 2027
Rivers: Mekong
Visit: Cambodia, Vietnam
Exclusive Savings
Inside
-
River View
-
Balcony
-
Suite
$3,309
From
US$3,309
Save 2,000
Per Person
View Trip
15 Day Timeless Wonders of Vietnam, Cambodia & the Mekong with Uniworld River Cruises
River Cruise
 (2)

15 Days Hanoi to Ho Chi Minh City
Cruise Line: Uniworld River Cruises
Ships: Mekong Jewel
Departures: Sep 2026 to Dec 2027
Rivers: Mekong
Visit: Vietnam, Cambodia
Early Booking Savings
Exclusive Savings
Inside
-
River View
-
Balcony
-
Suite
$5,599
From
US$6,399
Save 5,510
Per Person
View Trip
13 Day Treasures of the Mekong with Scenic
River Cruise
 (2)

13 Days Ho Chi Minh City to Siem Reap
Cruise Line: Scenic
Ships: Scenic Spirit
Departures: May 2026 to Dec 2027
Rivers: Mekong
Visit: Vietnam, Cambodia
Preferred Plus Fare + Reduced Air Offer
Select Fare
Exclusive Savings
Inside
-
River View
-
Balcony
$6,879
Suite
$8,830
From
US$7,513
Save 1,047
Per Person
View Trip
13 Day Wonders of Vietnam, Cambodia & the Mekong with Emerald Cruises
River Cruise
 (6)

13 Days Ho Chi Minh City to Siem Reap
Cruise Line: Emerald Cruises
Ships: Emerald Harmony
Departures: Apr 2026 to Nov 2027
Rivers: Mekong
Visit: Vietnam, Cambodia
Preferred Plus Fare + Reduced Air Offer
Exclusive Savings
Inside
-
River View
$4,355
Balcony
$5,042
Suite
$7,145
From
US$4,355
Save 218
Per Person
View Trip
16 Day Fascinating Vietnam, Cambodia & the Mekong River with Hanoi & Ha Long Bay (Northbound) with Avalon River Cruises
River Cruise
 (1)

16 Days Hanoi to Siem Reap
Cruise Line: Avalon River Cruises
Ship: Avalon Saigon
Departures: Aug 2026 to Nov 2027
Rivers: Mekong
Visit: Vietnam, Cambodia
Exclusive Savings
Inside
-
River View
-
Balcony
-
Suite
$6,784
From
US$6,784
Save 2,000
Per Person
View Trip
24 Day Grand Tour of Indochina with Emerald Cruises
River Cruise
 (6)

24 Days Hanoi to Bangkok
Cruise Line: Emerald Cruises
Ships: Emerald Harmony
Departures: Nov 2026 to Nov 2027
Rivers: Mekong
Visit: Vietnam, Cambodia, Laos, Thailand
Preferred Plus Fare + Reduced Air Offer
Exclusive Savings
Inside
-
River View
$9,151
Balcony
$9,622
Suite
$11,802
From
US$9,151
Save 204
Per Person
View Trip
21 Day Grand Tour of Vietnam & Cambodia with Emerald Cruises
River Cruise
 (6)

21 Days Hanoi to Siem Reap
Cruise Line: Emerald Cruises
Ship: Emerald Harmony
Departures: Nov 2026 to Nov 2027
Rivers: Mekong
Visit: Vietnam, Cambodia
Preferred Plus Fare + Reduced Air Offer
Exclusive Savings
Inside
-
River View
$7,011
Balcony
$7,482
Suite
$9,662
From
US$7,011
Save 204
Per Person
View Trip
15 Day Magnificent Mekong with Viking River Cruises
River Cruise
 (1)

15 Days Ho Chi Minh City to Hanoi
Cruise Line: Viking River Cruises
Ships: Viking Saigon, Viking Tonle
Departures: Aug 2026 to Dec 2028
Rivers: Mekong
Visit: Vietnam, Cambodia
Multiple Deals Available
Inside
-
River View
-
Balcony
$6,499
Suite
$10,999
From
US$6,499
Save 800
Per Person
View Trip
15 Day Magnificent Mekong with Viking River Cruises
River Cruise
 (1)

15 Days Hanoi to Ho Chi Minh City
Cruise Line: Viking River Cruises
Ships: Viking Saigon, Viking Tonle
Departures: Aug 2026 to Dec 2028
Rivers: Mekong
Visit: Cambodia, Vietnam
Multiple Deals Available
Inside
-
River View
-
Balcony
$6,499
Suite
$10,999
From
US$6,499
Save 1,000
Per Person
View Trip
8 Day Majestic Mekong Cruise with Emerald Cruises
River Cruise
 (6)

8 Days Ho Chi Minh City to Phnom Penh
Cruise Line: Emerald Cruises
Ships: Emerald Harmony
Departures: Apr 2026 to Nov 2027
Rivers: Mekong
Visit: Vietnam, Cambodia
Select Fare
Preferred Plus Fare + Reduced Air Offer
Exclusive Savings
Inside
-
River View
$2,726
Balcony
$3,554
Suite
$5,237
From
US$2,726
Save 269
Per Person
View Trip
13 Day Wonders of Cambodia, Vietnam & the Mekong with Emerald Cruises
River Cruise
 (6)

13 Days Siem Reap to Ho Chi Minh City
Cruise Line: Emerald Cruises
Ships: Emerald Harmony
Departures: Apr 2026 to Nov 2027
Rivers: Mekong
Visit: Cambodia, Vietnam
Select Fare
Preferred Plus Fare + Reduced Air Offer
Exclusive Savings
Inside
-
River View
$4,086
Balcony
$4,850
Suite
$6,597
From
US$4,086
Save 269
Per Person
View Trip
26 Day Wonders of Japan, Vietnam and Cambodia with Emerald Cruises
New ReleaseRiver Cruise
 (6)

26 Days Osaka to Siem Reap
Cruise Line: Emerald Cruises
Ship: Emerald Harmony
Departures: Oct 2026 to Apr 2027
Rivers: Mekong
Visit: Japan, Vietnam, Cambodia
Preferred Plus Fare + Reduced Air Offer
Exclusive Savings
Inside
-
River View
$14,746
Balcony
$15,217
Suite
$17,397
From
US$14,746
Per Person
View Trip
19 Day Fascinating Vietnam, Cambodia & the Mekong River with Hanoi, Ha Long Bay & Bangkok (Southbound) with Avalon River Cruises
River Cruise

19 Days Hanoi to Bangkok
Cruise Line: Avalon River Cruises
Ship: Avalon Saigon
Departures: Aug 2026 to Nov 2027
Rivers: Mekong
Visit: Vietnam, Cambodia, Thailand
Exclusive Savings
Inside
-
River View
-
Balcony
-
Suite
$8,079
From
US$8,079
Save 2,000
Per Person
View Trip
13 Day Treasures of the Mekong with Scenic
River Cruise

13 Days Siem Reap to Ho Chi Minh City
Cruise Line: Scenic
Ships: Scenic Spirit
Departures: Apr 2026 to Nov 2027
Rivers: Mekong
Visit: Cambodia, Vietnam
Select Fare
Preferred Plus Fare + Reduced Air Offer
Exclusive Savings
Inside
-
River View
-
Balcony
$6,041
Suite
$8,188
From
US$6,041
Save 511
Per Person
View Trip
11 Day Luxury Mekong and Temple Discovery Cruise with Scenic
River Cruise

11 Days Siem Reap to Ho Chi Minh City
Cruise Line: Scenic
Ships: Scenic Spirit
Departures: Apr 2026 to Nov 2027
Rivers: Mekong
Visit: Cambodia, Vietnam
Preferred Plus Fare + Reduced Air Offer
Exclusive Savings
Inside
-
River View
-
Balcony
$5,366
Suite
$8,197
From
US$5,366
Save 355
Per Person
View Trip
16 Day Riches of the Mekong with Hanoi, Ha Long Bay, Siem Reap and Ho Chi Minh City with AmaWaterways
New ReleaseRiver Cruise

16 Days Hanoi to Ho Chi Minh City
Cruise Line: AmaWaterways
Ship: AmaDara
Departure: 21 April 2026
Rivers: Mekong
Visit: Cambodia, Vietnam
Exclusive Savings
Inside
-
River View
-
Balcony
$6,277
Suite
-
From
US$6,277
Save 250
Per Person
View Trip
13 Day Fascinating Vietnam, Cambodia & the Mekong River (Northbound) with Avalon River Cruises
River Cruise

13 Days Ho Chi Minh City to Siem Reap
Cruise Line: Avalon River Cruises
Ship: Avalon Saigon
Departures: Aug 2026 to Nov 2027
Rivers: Mekong
Visit: Vietnam, Cambodia
Exclusive Savings
Inside
-
River View
-
Balcony
-
Suite
$5,304
From
US$5,304
Save 2,000
Per Person
View Trip
19 Day Fascinating Vietnam, Cambodia & the Mekong River with Hanoi, Ha Long Bay & Bangkok (Northbound) with Avalon River Cruises
River Cruise

19 Days Hanoi to Bangkok
Cruise Line: Avalon River Cruises
Ship: Avalon Saigon
Departures: Aug 2026 to Nov 2027
Rivers: Mekong
Visit: Vietnam, Cambodia, Thailand
Exclusive Savings
Inside
-
River View
-
Balcony
-
Suite
$8,034
From
US$8,034
Save 2,000
Per Person
View Trip
16 Day Wonders of Indochina and the Mekong with Emerald Cruises
River Cruise
 (6)

16 Days Ho Chi Minh City to Bangkok
Cruise Line: Emerald Cruises
Ships: Emerald Harmony
Departures: Oct 2026 to Nov 2027
Rivers: Mekong
Visit: Vietnam, Cambodia, Laos, Thailand
Preferred Plus Fare + Reduced Air Offer
Exclusive Savings
Inside
-
River View
$7,091
Balcony
$7,562
Suite
$9,742
From
US$7,091
Save 218
Per Person
View Trip
21 Day Grand Tour of Vietnam & Cambodia with Emerald Cruises
River Cruise
 (6)

21 Days Hanoi to Ho Chi Minh City
Cruise Line: Emerald Cruises
Ships: Emerald Harmony
Departures: Oct 2026 to Nov 2027
Rivers: Mekong
Visit: Vietnam, Cambodia
Preferred Plus Fare + Reduced Air Offer
Exclusive Savings
Inside
-
River View
$6,631
Balcony
$7,102
Suite
$9,662
From
US$6,631
Save 204
Per Person
View Trip
13 Day Riches of the Mekong with Siem Reap and Ho Chi Minh City with AmaWaterways
New ReleaseRiver Cruise

13 Days Siem Reap to Ho Chi Minh City
Cruise Line: AmaWaterways
Ship: AmaDara
Departure: 24 April 2026
Rivers: Mekong
Visit: Cambodia, Vietnam
Exclusive Savings
Inside
-
River View
-
Balcony
$4,496
Suite
-
From
US$4,496
Save 250
Per Person
View Trip
8 Day Majestic Mekong Cruise with Emerald Cruises
River Cruise
 (6)

8 Days Phnom Penh to Ho Chi Minh City
Cruise Line: Emerald Cruises
Ship: Emerald Harmony
Departures: Apr 2026 to May 2026
Rivers: Mekong
Visit: Cambodia, Vietnam
Select Fare
Exclusive Savings
Inside
-
River View
$2,726
Balcony
$3,490
Suite
$5,237
From
US$2,726
Save 269
Per Person
View Trip
13 Day Fascinating Vietnam, Cambodia & the Mekong River (Southbound) with Avalon River Cruises
River Cruise

13 Days Siem Reap to Ho Chi Minh City
Cruise Line: Avalon River Cruises
Ship: Avalon Saigon
Departures: Aug 2026 to Nov 2027
Rivers: Mekong
Visit: Cambodia, Vietnam
Exclusive Savings
Inside
-
River View
-
Balcony
-
Suite
$5,234
From
US$5,234
Save 2,000
Per Person
View Trip
16 Day Fascinating Vietnam, Cambodia & the Mekong River with Bangkok (Southbound) with Avalon River Cruises
River Cruise

16 Days Siem Reap to Bangkok
Cruise Line: Avalon River Cruises
Ship: Avalon Saigon
Departures: Aug 2026 to Nov 2027
Rivers: Mekong
Visit: Cambodia, Vietnam, Thailand
Exclusive Savings
Inside
-
River View
-
Balcony
-
Suite
$6,514
From
US$6,514
Save 2,000
Per Person
View Trip
17 Day Treasures & Temples of Vietnam & Cambodia with Emerald Cruises
River Cruise
 (6)

17 Days Hanoi to Siem Reap
Cruise Line: Emerald Cruises
Ships: Emerald Harmony
Departures: Apr 2026 to Nov 2027
Rivers: Mekong
Visit: Vietnam, Cambodia
Preferred Plus Fare + Reduced Air Offer
Exclusive Savings
Inside
-
River View
$5,936
Balcony
$6,407
Suite
$8,587
From
US$5,936
Save 204
Per Person
View Trip
23 Day Indochina Mekong Journey with Emerald Cruises
River Cruise
 (6)

23 Days Hanoi to Ho Chi Minh City
Cruise Line: Emerald Cruises
Ship: Emerald Harmony
Departures: Nov 2026 to Apr 2027
Rivers: Mekong
Visit: Vietnam, Laos, Cambodia
Preferred Plus Fare + Reduced Air Offer
Exclusive Savings
Inside
-
River View
$8,806
Balcony
$9,277
Suite
$11,837
From
US$8,806
Save 204
Per Person
View Trip
17 Day Treasures & Temples of Vietnam & Cambodia with Emerald Cruises
River Cruise
 (6)

17 Days Hanoi to Ho Chi Minh City
Cruise Line: Emerald Cruises
Ships: Emerald Harmony
Departures: Apr 2026 to Nov 2027
Rivers: Mekong
Visit: Vietnam, Cambodia
Select Fare
Preferred Plus Fare + Reduced Air Offer
Exclusive Savings
Inside
-
River View
$5,361
Balcony
$6,125
Suite
$7,872
From
US$5,361
Save 269
Per Person
View Trip
11 Day Luxury Mekong and Temple Discovery Cruise with Scenic
River Cruise

11 Days Ho Chi Minh City to Siem Reap
Cruise Line: Scenic
Ships: Scenic Spirit
Departures: May 2026 to Dec 2027
Rivers: Mekong
Visit: Vietnam, Cambodia
Preferred Plus Fare + Reduced Air Offer
Select Fare
Exclusive Savings
Inside
-
River View
-
Balcony
$5,366
Suite
$8,170
From
US$5,366
Save 496
Per Person
View Trip
25 Day Grand Indochina & Luxury Mekong with Scenic
River Cruise

25 Days Hanoi to Bangkok
Cruise Line: Scenic
Ship: Scenic Spirit
Departures: Oct 2026 to Oct 2027
Rivers: Mekong
Visit: Vietnam, Cambodia, Laos, Thailand
Preferred Plus Fare + Reduced Air Offer
Exclusive Savings
Inside
-
River View
-
Balcony
$14,227
Suite
$15,966
From
US$14,227
Save 467
Per Person
View Trip
Results: 1-30 of 44

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