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River Cruises from Siem Reap to Ho Chi Minh City

Are you looking for a river cruise from Siem Reap to Ho Chi Minh City? September is the most popular month to river cruise between Siem Reap and Ho Chi Minh City and there are 152 departures available from four of the world's leading river cruise lines.
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8 Days
15 Days
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$2,100pp
$11,855pp
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11 River Cruises (152 River Cruise Departures)
13 Day Wonders of Cambodia, Vietnam & the Mekong with Emerald Cruises
River Cruise
 (6)

13 Days Siem Reap to Ho Chi Minh City
Cruise Line: Emerald Cruises
Ships: Emerald Harmony
Departures: Apr 2026 to Nov 2027
Rivers: Mekong
Visit: Cambodia, Vietnam
Select Fare
Preferred Plus Fare + Reduced Air Offer
Exclusive Savings
Inside
-
River View
$4,086
Balcony
$4,532
Suite
$6,597
From
US$4,086
Save 269
Per Person
View Trip
13 Day Fascinating Vietnam, Cambodia & the Mekong River (Southbound) with Avalon River Cruises
River Cruise

13 Days Siem Reap to Ho Chi Minh City
Cruise Line: Avalon River Cruises
Ship: Avalon Saigon
Departures: Aug 2026 to Nov 2027
Rivers: Mekong
Visit: Cambodia, Vietnam
Exclusive Savings
Inside
-
River View
-
Balcony
-
Suite
$5,234
From
US$5,234
Save 2,000
Per Person
View Trip
13 Day Treasures of the Mekong with Scenic
River Cruise

13 Days Siem Reap to Ho Chi Minh City
Cruise Line: Scenic
Ships: Scenic Spirit
Departures: Apr 2026 to Nov 2027
Rivers: Mekong
Visit: Cambodia, Vietnam
Select Fare
Preferred Plus Fare + Reduced Air Offer
Exclusive Savings
Inside
-
River View
-
Balcony
$6,041
Suite
$8,188
From
US$6,041
Save 511
Per Person
View Trip
15 Day Wonders of Cambodia, Vietnam & the Mekong with Emerald Cruises
River Cruise
 (6)

15 Days Siem Reap to Ho Chi Minh City
Cruise Line: Emerald Cruises
Ships: Emerald Harmony
Departures: Jul 2026 to Dec 2027
Rivers: Mekong
Visit: Cambodia, Vietnam
Preferred Plus Fare + Reduced Air Offer
Select Fare
Exclusive Savings
Inside
-
River View
$4,953
Balcony
$5,187
Suite
$7,367
From
US$4,953
Save 200
Per Person
View Trip
10 Day Riches of the Mekong with Ho Chi Minh City with AmaWaterways
New ReleaseRiver Cruise

10 Days Siem Reap to Ho Chi Minh City
Cruise Line: AmaWaterways
Ship: AmaDara
Departure: 27 April 2026
Rivers: Mekong
Visit: Cambodia, Vietnam
Exclusive Savings
Inside
-
River View
-
Balcony
$3,997
Suite
-
From
US$3,997
Save 250
Per Person
View Trip
15 Day Treasures of the Mekong Meandering Cruise with Scenic
River Cruise

15 Days Siem Reap to Ho Chi Minh City
Cruise Line: Scenic
Ship: Scenic Spirit
Departures: Jul 2026 to Dec 2027
Rivers: Mekong
Visit: Cambodia, Vietnam
Preferred Plus Fare + Reduced Air Offer
Exclusive Savings
Inside
-
River View
-
Balcony
$7,848
Suite
$10,679
From
US$7,848
Save 468
Per Person
View Trip
11 Day Luxury Mekong and Temple Discovery Cruise with Scenic
River Cruise

11 Days Siem Reap to Ho Chi Minh City
Cruise Line: Scenic
Ships: Scenic Spirit
Departures: Apr 2026 to Nov 2027
Rivers: Mekong
Visit: Cambodia, Vietnam
Preferred Plus Fare + Reduced Air Offer
Exclusive Savings
Inside
-
River View
-
Balcony
$5,366
Suite
$8,197
From
US$5,366
Save 360
Per Person
View Trip
8 Day Riches of the Mekong with AmaWaterways
New ReleaseRiver Cruise

8 Days Siem Reap to Ho Chi Minh City
Cruise Line: AmaWaterways
Ships: AmaDara, AmaMaya
Departures: Apr 2026 to Dec 2027
Rivers: Mekong
Visit: Cambodia, Vietnam
Exclusive Savings
Inside
-
River View
-
Balcony
$2,129
Suite
$3,848
From
US$2,129
Save 1,250
Per Person
View Trip
13 Day Riches of the Mekong with Siem Reap and Ho Chi Minh City with AmaWaterways
New ReleaseRiver Cruise

13 Days Siem Reap to Ho Chi Minh City
Cruise Line: AmaWaterways
Ship: AmaDara
Departure: 24 April 2026
Rivers: Mekong
Visit: Cambodia, Vietnam
Exclusive Savings
Inside
-
River View
-
Balcony
$4,796
Suite
-
From
US$4,796
Save 250
Per Person
View Trip
11 Day Riches of the Mekong with Siem Reap with AmaWaterways
New ReleaseRiver Cruise

11 Days Siem Reap to Ho Chi Minh City
Cruise Line: AmaWaterways
Ship: AmaDara
Departure: 24 April 2026
Rivers: Mekong
Visit: Cambodia, Vietnam
Exclusive Savings
Inside
-
River View
-
Balcony
$4,397
Suite
-
From
US$4,397
Save 250
Per Person
View Trip
13 Day Temple Discovery and Meandering along the Mekong Cruise with Scenic
River Cruise

13 Days Siem Reap to Ho Chi Minh City
Cruise Line: Scenic
Ship: Scenic Spirit
Departures: Jul 2026 to Dec 2027
Rivers: Mekong
Visit: Cambodia, Vietnam
Preferred Plus Fare + Reduced Air Offer
Exclusive Savings
Inside
-
River View
-
Balcony
$7,173
Suite
$10,004
From
US$7,173
Save 468
Per Person
View Trip
Results: 11 results

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River Cruises from Siem Reap to Ho Chi Minh City

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