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River Cruises from Siem Reap to Ho Chi Minh City

Are you looking for a river cruise from Siem Reap to Ho Chi Minh City? April, September and January are the most popular months to river cruise between Siem Reap and Ho Chi Minh City and there are 237 departures available from four of the world's leading river cruise lines.
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8 Days
15 Days
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$25,395pp
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11 River Cruises (237 River Cruise Departures)
13 Day Wonders of Cambodia, Vietnam & the Mekong with Emerald Cruises
River Cruise
 (4)

13 Days Siem Reap to Ho Chi Minh City
Cruise Line: Emerald Cruises
Ship: Emerald Harmony
Departures: Oct 2025 to May 2027
Rivers: Mekong
Visit: Cambodia, Vietnam
Early Payment Discount
Fly Free Economy
Exclusive Savings
Inside
-
River View
$5,304
Balcony
$5,799
Suite
$8,076
From
US$5,304
Save 6,349
Per Person
View Trip
13 Day Temple Discovery and Meandering along the Mekong Cruise with Scenic
River Cruise

13 Days Siem Reap to Ho Chi Minh City
Cruise Line: Scenic
Ship: Scenic Spirit
Departures: Sep 2025 to Dec 2026
Rivers: Mekong
Visit: Cambodia, Vietnam
Fly Free Economy
Early Booking Savings
Exclusive Savings
Inside
-
River View
-
Balcony
$6,690
Suite
$8,670
From
US$6,690
Save 13,145
Per Person
View Trip
15 Day Wonders of Cambodia, Vietnam & the Mekong with Emerald Cruises
River Cruise
 (4)

15 Days Siem Reap to Ho Chi Minh City
Cruise Line: Emerald Cruises
Ships: Emerald Harmony
Departures: Sep 2025 to Dec 2026
Rivers: Mekong
Visit: Cambodia, Vietnam
Early Payment Discount
Fly Free Economy
Exclusive Savings
Inside
-
River View
$5,305
Balcony
$6,221
Suite
$15,596
From
US$5,305
Save 6,045
Per Person
View Trip
15 Day Treasures of the Mekong Meandering Cruise with Scenic
River Cruise

15 Days Siem Reap to Ho Chi Minh City
Cruise Line: Scenic
Ship: Scenic Spirit
Departures: Sep 2025 to Dec 2026
Rivers: Mekong
Visit: Cambodia, Vietnam
Fly Free Economy
Early Booking Savings
Exclusive Savings
Inside
-
River View
-
Balcony
$7,350
Suite
$9,330
From
US$7,350
Save 13,145
Per Person
View Trip
13 Day Treasures of the Mekong with Scenic
River Cruise

13 Days Siem Reap to Ho Chi Minh City
Cruise Line: Scenic
Ship: Scenic Spirit
Departures: Oct 2025 to May 2027
Rivers: Mekong
Visit: Cambodia, Vietnam
Fly Free Economy
Early Booking Savings
Exclusive Savings
Inside
-
River View
-
Balcony
$7,250
Suite
$9,230
From
US$7,250
Save 12,745
Per Person
View Trip
8 Day Riches of the Mekong with AmaWaterways
New ReleaseRiver Cruise

8 Days Siem Reap to Ho Chi Minh City
Cruise Line: AmaWaterways
Ships: AmaDara, AmaMaya
Departures: Feb 2026 to Dec 2027
Rivers: Mekong
Visit: Cambodia, Vietnam
Exclusive Savings
Inside
-
River View
-
Balcony
$1,929
Suite
$3,819
From
US$1,929
Save 1,308
Per Person
View Trip
13 Day Riches of the Mekong with Siem Reap and Ho Chi Minh City with AmaWaterways
New ReleaseRiver Cruise

13 Days Siem Reap to Ho Chi Minh City
Cruise Line: AmaWaterways
Ships: AmaDara, AmaMaya
Departures: Jan 2026 to Apr 2027
Rivers: Mekong
Visit: Cambodia, Vietnam
Exclusive Savings
Inside
-
River View
-
Balcony
$3,933
Suite
$5,097
From
US$3,933
Save 653
Per Person
View Trip
13 Day Fascinating Vietnam, Cambodia & the Mekong River (Southbound) with Avalon River Cruises
River Cruise

13 Days Siem Reap to Ho Chi Minh City
Cruise Line: Avalon River Cruises
Ships: Avalon Saigon
Departures: Oct 2025 to Nov 2027
Rivers: Mekong
Visit: Cambodia, Vietnam
Exclusive Savings
Inside
-
River View
-
Balcony
-
Suite
$5,082
From
US$4,713
Save 2,181
Per Person
View Trip
10 Day Riches of the Mekong with Ho Chi Minh City with AmaWaterways
New ReleaseRiver Cruise

10 Days Siem Reap to Ho Chi Minh City
Cruise Line: AmaWaterways
Ships: AmaDara, AmaMaya
Departures: Feb 2026 to Apr 2027
Rivers: Mekong
Visit: Cambodia, Vietnam
Exclusive Savings
Inside
-
River View
-
Balcony
$2,964
Suite
$4,515
From
US$2,964
Save 623
Per Person
View Trip
11 Day Luxury Mekong and Temple Discovery Cruise with Scenic
River Cruise

11 Days Siem Reap to Ho Chi Minh City
Cruise Line: Scenic
Ship: Scenic Spirit
Departures: Oct 2025 to May 2027
Rivers: Mekong
Visit: Cambodia, Vietnam
Fly Free Economy
Early Booking Savings
Exclusive Savings
Inside
-
River View
-
Balcony
$6,590
Suite
$8,570
From
US$6,590
Save 12,745
Per Person
View Trip
11 Day Riches of the Mekong with Siem Reap with AmaWaterways
New ReleaseRiver Cruise

11 Days Siem Reap to Ho Chi Minh City
Cruise Line: AmaWaterways
Ships: AmaDara, AmaMaya
Departures: Jan 2026 to Apr 2027
Rivers: Mekong
Visit: Cambodia, Vietnam
Exclusive Savings
Inside
-
River View
-
Balcony
$3,546
Suite
$5,097
From
US$3,546
Save 641
Per Person
View Trip
Results: 11 results

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River Cruises from Siem Reap to Ho Chi Minh City

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