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River Cruises from Siem Reap to Ho Chi Minh City

Are you looking for a river cruise from Siem Reap to Ho Chi Minh City? April and September are the most popular months to river cruise between Siem Reap and Ho Chi Minh City and there are 181 departures available from four of the world's leading river cruise lines.
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8 Days
15 Days
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$22,795pp
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12 River Cruises (181 River Cruise Departures)
13 Day Wonders of Cambodia, Vietnam & the Mekong with Emerald Cruises
River Cruise
 (5)

13 Days Siem Reap to Ho Chi Minh City
Cruise Line: Emerald Cruises
Ships: Emerald Harmony
Departures: Feb 2026 to Nov 2027
Rivers: Mekong
Visit: Cambodia, Vietnam
Early Payment Discount
Exclusive Savings
Inside
-
River View
$4,621
Balcony
$5,106
Suite
$7,337
From
US$4,621
Save 7,179
Per Person
View Trip
13 Day Fascinating Vietnam, Cambodia & the Mekong River (Southbound) with Avalon River Cruises
River Cruise

13 Days Siem Reap to Ho Chi Minh City
Cruise Line: Avalon River Cruises
Ship: Avalon Saigon
Departures: Feb 2026 to Nov 2027
Rivers: Mekong
Visit: Cambodia, Vietnam
Exclusive Savings
Inside
-
River View
-
Balcony
-
Suite
$5,032
From
US$5,032
Save 2,242
Per Person
View Trip
11 Day Luxury Mekong and Temple Discovery Cruise with Scenic
River Cruise

11 Days Siem Reap to Ho Chi Minh City
Cruise Line: Scenic
Ships: Scenic Spirit
Departures: Apr 2026 to Nov 2027
Rivers: Mekong
Visit: Cambodia, Vietnam
Multiple Deals Available
Inside
-
River View
-
Balcony
$5,931
Suite
$8,821
From
US$5,931
Save 12,145
Per Person
View Trip
11 Day Enchanting Mekong and Siem Reap with Emerald Cruises
New ReleaseRiver Cruise
 (5)

11 Days Siem Reap to Ho Chi Minh City
Cruise Line: Emerald Cruises
Ship: Emerald Harmony
Departures: Feb 2026 to Feb 2026
Rivers: Mekong
Visit: Cambodia, Vietnam
Early Payment Discount
Exclusive Savings
Inside
-
River View
$5,145
Balcony
$6,758
Suite
-
From
US$5,145
Save 6,545
Per Person
View Trip
13 Day Treasures of the Mekong with Scenic
River Cruise

13 Days Siem Reap to Ho Chi Minh City
Cruise Line: Scenic
Ships: Scenic Spirit
Departures: Apr 2026 to Nov 2027
Rivers: Mekong
Visit: Cambodia, Vietnam
Multiple Deals Available
Inside
-
River View
-
Balcony
$6,586
Suite
$8,962
From
US$6,586
Save 12,165
Per Person
View Trip
15 Day Wonders of Cambodia, Vietnam & the Mekong with Emerald Cruises
River Cruise
 (5)

15 Days Siem Reap to Ho Chi Minh City
Cruise Line: Emerald Cruises
Ships: Emerald Harmony
Departures: Jul 2026 to Dec 2027
Rivers: Mekong
Visit: Cambodia, Vietnam
Early Payment Discount
Exclusive Savings
Inside
-
River View
$5,365
Balcony
$5,850
Suite
$8,081
From
US$5,365
Save 6,868
Per Person
View Trip
11 Day Riches of the Mekong with Siem Reap with AmaWaterways
New ReleaseRiver Cruise

11 Days Siem Reap to Ho Chi Minh City
Cruise Line: AmaWaterways
Ship: AmaDara
Departures: Feb 2026 to Apr 2026
Rivers: Mekong
Visit: Cambodia, Vietnam
Exclusive Savings
Inside
-
River View
-
Balcony
$4,088
Suite
$5,719
From
US$4,088
Save 188
Per Person
View Trip
8 Day Riches of the Mekong with AmaWaterways
New ReleaseRiver Cruise

8 Days Siem Reap to Ho Chi Minh City
Cruise Line: AmaWaterways
Ships: AmaDara, AmaMaya
Departures: Feb 2026 to Dec 2027
Rivers: Mekong
Visit: Cambodia, Vietnam
Exclusive Savings
Inside
-
River View
-
Balcony
$1,959
Suite
$3,704
From
US$1,959
Save 1,328
Per Person
View Trip
10 Day Riches of the Mekong with Ho Chi Minh City with AmaWaterways
New ReleaseRiver Cruise

10 Days Siem Reap to Ho Chi Minh City
Cruise Line: AmaWaterways
Ship: AmaDara
Departures: Feb 2026 to Apr 2026
Rivers: Mekong
Visit: Cambodia, Vietnam
Exclusive Savings
Inside
-
River View
-
Balcony
$3,704
Suite
$5,335
From
US$3,704
Save 172
Per Person
View Trip
13 Day Temple Discovery and Meandering along the Mekong Cruise with Scenic
River Cruise

13 Days Siem Reap to Ho Chi Minh City
Cruise Line: Scenic
Ship: Scenic Spirit
Departures: Jul 2026 to Dec 2027
Rivers: Mekong
Visit: Cambodia, Vietnam
Multiple Deals Available
Inside
-
River View
-
Balcony
$7,009
Suite
$8,420
From
US$7,009
Save 9,753
Per Person
View Trip
13 Day Riches of the Mekong with Siem Reap and Ho Chi Minh City with AmaWaterways
New ReleaseRiver Cruise

13 Days Siem Reap to Ho Chi Minh City
Cruise Line: AmaWaterways
Ship: AmaDara
Departures: Feb 2026 to Apr 2026
Rivers: Mekong
Visit: Cambodia, Vietnam
Exclusive Savings
Inside
-
River View
-
Balcony
$4,471
Suite
$6,102
From
US$4,471
Save 204
Per Person
View Trip
15 Day Treasures of the Mekong Meandering Cruise with Scenic
River Cruise

15 Days Siem Reap to Ho Chi Minh City
Cruise Line: Scenic
Ship: Scenic Spirit
Departures: Jul 2026 to Dec 2027
Rivers: Mekong
Visit: Cambodia, Vietnam
Multiple Deals Available
Inside
-
River View
-
Balcony
$7,649
Suite
$9,061
From
US$7,649
Save 9,283
Per Person
View Trip
Results: 12 results

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River Cruises from Siem Reap to Ho Chi Minh City

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