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River Cruises from Ho Chi Minh City to Siem Reap

Are you looking for a river cruise from Ho Chi Minh City to Siem Reap? September is the most popular month to river cruise between Ho Chi Minh City and Siem Reap and there are 149 departures available from four of the world's leading river cruise lines.
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15 Days
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$11,855pp
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9 River Cruises (149 River Cruise Departures)
13 Day Treasures of the Mekong with Scenic
River Cruise
 (2)

13 Days Ho Chi Minh City to Siem Reap
Cruise Line: Scenic
Ships: Scenic Spirit
Departures: May 2026 to Dec 2027
Rivers: Mekong
Visit: Vietnam, Cambodia
Preferred Plus Fare + Reduced Air Offer
Exclusive Savings
Inside
-
River View
-
Balcony
$6,041
Suite
$8,830
From
US$6,041
Save 355
Per Person
View Trip
13 Day Wonders of Vietnam, Cambodia & the Mekong with Emerald Cruises
River Cruise
 (6)

13 Days Ho Chi Minh City to Siem Reap
Cruise Line: Emerald Cruises
Ships: Emerald Harmony
Departures: May 2026 to Nov 2027
Rivers: Mekong
Visit: Vietnam, Cambodia
Preferred Plus Fare + Reduced Air Offer
Exclusive Savings
Inside
-
River View
$4,355
Balcony
$5,042
Suite
$7,145
From
US$4,355
Save 264
Per Person
View Trip
15 Day Wonders of Vietnam, Cambodia & the Mekong with Emerald Cruises
River Cruise
 (6)

15 Days Ho Chi Minh City to Siem Reap
Cruise Line: Emerald Cruises
Ships: Emerald Harmony
Departures: Aug 2026 to Dec 2027
Rivers: Mekong
Visit: Vietnam, Cambodia
Preferred Plus Fare + Reduced Air Offer
Select Fare
Exclusive Savings
Inside
-
River View
$4,716
Balcony
$5,187
Suite
$7,367
From
US$4,716
Save 182
Per Person
View Trip
15 Day Treasures of the Mekong Meandering Cruise with Scenic
River Cruise

15 Days Ho Chi Minh City to Siem Reap
Cruise Line: Scenic
Ship: Scenic Spirit
Departures: Jul 2026 to Dec 2027
Rivers: Mekong
Visit: Vietnam, Cambodia
Preferred Plus Fare + Reduced Air Offer
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
River View
-
Balcony
$7,221
Suite
$8,385
From
US$7,221
Save 2,534
Per Person
View Trip
13 Day Fascinating Vietnam, Cambodia & the Mekong River (Northbound) with Avalon River Cruises
River Cruise

13 Days Ho Chi Minh City to Siem Reap
Cruise Line: Avalon River Cruises
Ship: Avalon Saigon
Departures: Aug 2026 to Nov 2027
Rivers: Mekong
Visit: Vietnam, Cambodia
Exclusive Savings
Inside
-
River View
-
Balcony
-
Suite
$5,324
From
US$5,324
Save 2,000
Per Person
View Trip
13 Day Meandering along the Mekong and Temple Discovery Cruise with Scenic
River Cruise

13 Days Ho Chi Minh City to Siem Reap
Cruise Line: Scenic
Ship: Scenic Spirit
Departures: Jul 2026 to Dec 2027
Rivers: Mekong
Visit: Vietnam, Cambodia
Preferred Plus Fare + Reduced Air Offer
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
River View
-
Balcony
$6,546
Suite
$7,710
From
US$6,546
Save 2,534
Per Person
View Trip
8 Day Charms of the Mekong (Smithsonian Journeys) with AmaWaterways
New ReleaseRiver Cruise

8 Days Ho Chi Minh City to Siem Reap
Cruise Line: AmaWaterways
Ships: AmaDara, AmaMaya
Departures: Feb 2027 to Oct 2027
Rivers: Mekong
Visit: Vietnam, Cambodia
Exclusive Savings
Inside
-
River View
-
Balcony
$4,328
Suite
$5,628
From
US$4,328
Save 250
Per Person
View Trip
11 Day Luxury Mekong and Temple Discovery Cruise with Scenic
River Cruise

11 Days Ho Chi Minh City to Siem Reap
Cruise Line: Scenic
Ships: Scenic Spirit
Departures: May 2026 to Dec 2027
Rivers: Mekong
Visit: Vietnam, Cambodia
Preferred Plus Fare + Reduced Air Offer
Exclusive Savings
Inside
-
River View
-
Balcony
$5,366
Suite
$8,170
From
US$5,366
Save 355
Per Person
View Trip
8 Day Charms of the Mekong with AmaWaterways
New ReleaseRiver Cruise

8 Days Ho Chi Minh City to Siem Reap
Cruise Line: AmaWaterways
Ships: AmaDara, AmaMaya
Departures: Aug 2026 to Dec 2027
Rivers: Mekong
Visit: Vietnam, Cambodia
Exclusive Savings
Inside
-
River View
-
Balcony
$2,029
Suite
$3,928
From
US$2,029
Save 1,250
Per Person
View Trip
Results: 9 results

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