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Royal Caribbean Cruises from Colon

Start your journey from Colon with 18 unique Royal Caribbean cruise itineraries to choose from. March, April and January are the most popular months to begin your cruise from Colon and Royal Caribbean have 79 trips departing this season.
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18 Cruises (79 Cruise Departures)
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 18 March 2028
Visit: Panama, Colombia, Curacao, Aruba
Bonus Onboard Credit
Exclusive Savings
Inside
$919
Oceanview
$1,049
Balcony
$1,469
Suite
$1,499
From
US$919
Save 508
Per Person
View Trip
8 Day Colon To San Juan Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to San Juan
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 24 April 2027
Visit: Panama, Saint Vincent, Saint Lucia, Antigua and Barbuda, Virgin Islands, Puerto Rico
Bonus Onboard Credit
Exclusive Savings
Inside
$618
Oceanview
$669
Balcony
$1,168
Suite
$1,268
From
US$618
Save 375
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ships: Grandeur of the Seas, Serenade of the Seas
Departures: Feb 2026 to Jan 2028
Visit: Panama, Colombia, Aruba, Curacao
Bonus Onboard Credit
Exclusive Savings
Inside
$861
Oceanview
$981
Balcony
$1,213
Suite
$1,390
From
US$861
Save 610
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 28 March 2026
Visit: Panama, Colombia, Aruba, Bonaire
Exclusive Savings
Inside
$1,148
Oceanview
$1,188
Balcony
$1,279
Suite
$1,728
From
US$1,148
Save 611
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 10 April 2027
Visit: Panama, Colombia, Aruba, Bonaire, Curacao
Bonus Onboard Credit
Exclusive Savings
Inside
$908
Oceanview
$1,037
Balcony
$1,477
Suite
$1,507
From
US$908
Save 501
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Mar 2027 to Mar 2027
Visit: Panama, Colombia, Curacao, Bonaire, Aruba
Bonus Onboard Credit
Exclusive Savings
Inside
$884
Oceanview
$1,005
Balcony
$1,434
Suite
$1,464
From
US$884
Save 514
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ships: Grandeur of the Seas, Serenade of the Seas
Departures: Feb 2026 to Feb 2027
Visit: Panama, Colombia, Aruba, Bonaire
Bonus Onboard Credit
Exclusive Savings
Inside
$773
Oceanview
$883
Balcony
$1,273
Suite
$1,283
From
US$773
Save 878
Per Person
View Trip
8 Day Southern Caribbean Holiday Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 19 December 2026
Visit: Panama, Colombia, Aruba, Bonaire
Bonus Onboard Credit
Exclusive Savings
Inside
$1,004
Oceanview
$1,014
Balcony
$1,546
Suite
$1,677
From
US$1,004
Save 550
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 30 January 2027
Visit: Panama, Colombia, Curacao, Aruba, Bonaire
Bonus Onboard Credit
Exclusive Savings
Inside
$809
Oceanview
$919
Balcony
$1,308
Suite
$1,328
From
US$809
Save 458
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ships: Grandeur of the Seas, Serenade of the Seas
Departures: Mar 2026 to Apr 2028
Visit: Panama, Colombia, Curacao, Aruba
Bonus Onboard Credit
Exclusive Savings
Inside
$797
Oceanview
$907
Balcony
$1,253
Suite
$1,316
From
US$797
Save 593
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Sep 2026 to Apr 2028
Visit: Panama, Colombia, Bonaire, Aruba, Curacao
Bonus Onboard Credit
Exclusive Savings
Inside
$939
Oceanview
$960
Balcony
$1,282
Suite
$1,567
From
US$939
Save 525
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jan 2028 to Apr 2028
Visit: Panama, Colombia, Curacao, Aruba
Bonus Onboard Credit
Exclusive Savings
Inside
$839
Oceanview
$949
Balcony
$1,329
Suite
$1,348
From
US$839
Save 542
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: May 2026 to Apr 2028
Visit: Panama, Colombia, Aruba, Curacao
Bonus Onboard Credit
Exclusive Savings
Inside
$671
Oceanview
$688
Balcony
$1,029
Suite
$1,102
From
US$671
Save 649
Per Person
View Trip
11 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

11 Days (10 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 14 November 2026
Visit: Panama, Bonaire, Aruba, Curacao, Trinidad and Tobago
Bonus Onboard Credit
Exclusive Savings
Inside
$1,016
Oceanview
$1,154
Balcony
$1,693
Suite
$1,811
From
US$1,016
Save 548
Per Person
View Trip
11 Day Panama Canal Westward Cruise with Royal Caribbean
Cruise

11 Days (10 Nights) Colon to Los Angeles
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 25 April 2026
Visit: Panama, Costa Rica, Mexico, USA
Exclusive Savings
Inside
$845
Oceanview
$925
Balcony
$1,792
Suite
-
From
US$845
Save 348
Per Person
View Trip
2 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

2 Days (1 Nights) Colon to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 18 April 2026
Visit: Panama, Colombia
Exclusive Savings
Inside
$150
Oceanview
$141
Balcony
$143
Suite
$273
From
US$141
Save 126
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Feb 2026 to Feb 2026
Visit: Panama, Colombia, Bonaire, Aruba
Exclusive Savings
Inside
$1,209
Oceanview
$1,228
Balcony
$1,328
Suite
$1,369
From
US$1,209
Save 666
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 07 March 2026
Visit: Panama, Colombia, Aruba, Curacao
Exclusive Savings
Inside
-
Oceanview
$1,102
Balcony
$1,222
Suite
$1,862
From
US$1,102
Save 589
Per Person
View Trip
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