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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? April, May and September are the most popular months to cruise between Spain and Italy and there are 216 departures available from sixteen of the world's leading cruise lines.
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112 Cruises (216 Cruise Departures)
8 Day A Journey from Barcelona to Rome with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 09 September 2024
Countries Visited: Spain, France, Corsica, Italy
Exclusive DealUnique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$6,816
SUITE
$8,286
From 6,816
View Trip
15 Day Italy And Adriatic with Cunard
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 27 July 2026
Countries Visited: Spain, Italy, Sicily, Greece (+3 more), Montenegro, Croatia, Malta
INSIDE
$3,320
OCEANVIEW
$3,667
BALCONY
$4,162
SUITE
$8,914
From 3,320
View Trip
8 Day A Journey From Barcelona To Civitavecchia with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departures: Jun 2025 to Sep 2025
Countries Visited: Spain, France, Italy
Unique EscapesPenthouse Dream Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,846
SUITE
$7,108
From 5,846
View Trip
11 Day Mediterranean Overture with Seabourn
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Ovation
Departures: May 2025 to Oct 2025
Countries Visited: Spain, France, Monaco, Italy (+2 more), Corsica, Sardinia
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$8,424
SUITE
$15,913
From 8,424
View Trip
31 Day Jewels Of Spain, Italy & France with Seabourn
Cruise

31 Days (30 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Ovation
Departure: 15 April 2025
Countries Visited: Spain, Sardinia, France, Italy (+4 more), Monaco, Sicily, Malta, Corsica
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$24,432
SUITE
-
From 24,432
View Trip
8 Day Central Mediterranean with Cunard
Cruise

8 Days (7 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 18 August 2025
Countries Visited: Spain, Malta, Italy, Croatia
INSIDE
$1,516
OCEANVIEW
$1,694
BALCONY
$1,962
SUITE
$4,189
From 1,516
View Trip
5 Day MSC Grand Voyages with MSC Cruises
Cruise

5 Days (4 Nights) Alicante to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 26 November 2024
Countries Visited: Spain, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
$600
BALCONY
$758
SUITE
$1,421
From 600
View Trip
8 Day Spain, France & Italy Cruise with Celebrity Cruises
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 06 July 2024
Countries Visited: Spain, France, Italy
Exclusive Offer
INSIDE
$2,243
OCEANVIEW
$2,575
BALCONY
$3,354
SUITE
$7,207
Save 2,642
From 2,243
View Trip
8 Day France And Italy with Cunard
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 16 June 2025
Countries Visited: Spain, France, Sardinia, Sicily (+1 more), Italy
INSIDE
$1,338
OCEANVIEW
$1,556
BALCONY
$1,783
SUITE
$3,744
From 1,338
View Trip
11 Day Art De Vivre Experience with Regent Seven Seas
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 22 July 2025
Countries Visited: Spain, France, Monaco, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$13,238
SUITE
$14,198
Save 7,572
From 13,238
View Trip
12 Day Barcelona to Rome with Silversea
Cruise

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Ray
Departure: 26 April 2025
Countries Visited: Spain, France, Monaco, Italy
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$14,553
From 14,553
View Trip
15 Day Adriatic And Western Mediterranean with Cunard
Cruise

15 Days (14 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departures: May 2026 to Jun 2026
Countries Visited: Spain, Corsica, Sicily, Italy (+3 more), Greece, Montenegro, Croatia
INSIDE
$2,974
OCEANVIEW
$3,320
BALCONY
$3,766
SUITE
$7,924
From 2,974
View Trip
15 Day Italy And Adriatic with Cunard
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 18 August 2025
Countries Visited: Spain, Malta, Italy, Croatia (+2 more), Montenegro, Greece
INSIDE
$2,766
OCEANVIEW
$3,212
BALCONY
$3,657
SUITE
$7,667
From 2,766
View Trip
8 Day A Journey From Barcelona To Rome with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 13 May 2025
Countries Visited: Spain, France, Corsica, Sardinia (+1 more), Italy
Unique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$6,192
SUITE
$7,529
From 6,192
View Trip
13 Day Vita Est Bona with Regent Seven Seas
Cruise

13 Days (12 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 24 August 2024
Countries Visited: Spain, France, Monaco, Italy (+1 more), Sardinia
Explore More OfferExclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$10,579
SUITE
$11,723
Save 11,141
From 10,579
View Trip
8 Day Iconic Western Mediterranean with Viking Cruises
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+6 more), Viking Saturn, Viking Sky, Viking Star, Viking Vela, Viking Venus, Viking Vesta
Departures: Sep 2024 to Jul 2026
Countries Visited: Spain, France, Monaco, Italy
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$4,450
SUITE
$6,925
Save 1,178
From 4,450
View Trip
10 Day A Journey from Barcelona to Rome with Explora Journeys
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 14 April 2025
Countries Visited: Spain, Sardinia, Tunisia, Sicily (+1 more), Italy
Unique EscapesPenthouse Dream Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$8,118
SUITE
$9,930
From 8,118
View Trip
3 Day Mediterranean with MSC Cruises
Cruise

3 Days (2 Nights) Barcelona to Genoa
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 08 June 2024
Countries Visited: Spain, France, Italy
Exclusive Deal
INSIDE
$324
OCEANVIEW
$403
BALCONY
$492
SUITE
-
From 324
View Trip
10 Day Greece, Malta & Turkey Cruise with Celebrity Cruises
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 30 August 2025
Countries Visited: Spain, Malta, Greece, Turkey (+1 more), Italy
Exclusive Offer
INSIDE
$2,470
OCEANVIEW
$2,796
BALCONY
$3,164
SUITE
$9,486
Save 3,325
From 2,470
View Trip
15 Day Italy, France And Spain with Cunard
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 July 2025
Countries Visited: Spain, Corsica, France, Italy (+2 more), Sardinia, Sicily
INSIDE
$2,855
OCEANVIEW
$3,033
BALCONY
$3,568
SUITE
$7,399
From 2,855
View Trip
15 Day Italy, France And Spain with Cunard
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departures: May 2026 to Jun 2026
Countries Visited: Spain, France, Italy, Corsica (+1 more), Sicily
INSIDE
$2,726
OCEANVIEW
$2,974
BALCONY
$3,370
SUITE
$7,231
From 2,726
View Trip
4 Day MSC Grand Voyages with MSC Cruises
Cruise

4 Days (3 Nights) Valencia to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 27 November 2024
Countries Visited: Spain, Italy
Exclusive Deal
INSIDE
$480
OCEANVIEW
$569
BALCONY
$678
SUITE
$1,242
From 480
View Trip
22 Day Barcelona to Venice with Silversea
Cruise

22 Days (21 Nights) Barcelona to Venice
Cruise Line: Silversea
Ship: Silver Moon
Departure: 16 August 2024
Countries Visited: Spain, France, Italy, Sardinia (+4 more), Sicily, Malta, Montenegro, Croatia
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$21,780
BALCONY
$23,562
SUITE
-
From 21,780
View Trip
11 Day Mediterranean Overture with Seabourn
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Ovation
Departure: 12 July 2024
Countries Visited: Spain, France, Monaco, Italy (+2 more), Corsica, Sardinia
More Moments On Us Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$11,394
SUITE
$19,809
From 11,394
View Trip
11 Day Hadrian's Homecoming with Oceania Cruises
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Vista
Departure: 03 October 2024
Countries Visited: Spain, France, Monaco, Italy (+4 more), Corsica, Sardinia, Sicily, Malta
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$13,903
SUITE
-
Save 2,127
From 13,903
View Trip
21 Day France & Spanish Treasures with Seabourn
Cruise

21 Days (20 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Ovation
Departure: 10 October 2024
Countries Visited: Spain, France, Tunisia, Italy (+2 more), Sicily, Malta
More Moments On Us Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$20,809
SUITE
-
From 20,809
View Trip
6 Day Barcelona to Rome with Silversea
Cruise

6 Days (5 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Ray
Departure: 22 June 2024
Countries Visited: Spain, France, Italy
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$9,801
From 9,801
View Trip
13 Day Barcelona to Rome with Silversea
Cruise

13 Days (12 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Ray
Departure: 18 May 2025
Countries Visited: Spain, France, Monaco, Italy
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$18,315
From 18,315
View Trip
8 Day Italy, France And Spain with Cunard
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 September 2026
Countries Visited: Spain, Corsica, Sicily, Italy
INSIDE
$1,635
OCEANVIEW
$1,783
BALCONY
$1,932
SUITE
$4,258
From 1,635
View Trip
13 Day Barcelona to Cannes, Rome & Tuscany with Virgin Voyages
Cruise

13 Days (12 Nights) Barcelona to Rome
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 25 September 2025
Countries Visited: Spain, France, Corsica, Sardinia (+1 more), Italy
INSIDE
$4,133
OCEANVIEW
$4,269
BALCONY
$4,699
SUITE
$10,498
From 4,133
View Trip
Results: 31-60 of 112

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