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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? August, April and May are the most popular months to cruise between Spain and Italy and there are 208 departures available from sixteen of the world's leading cruise lines.
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112 Cruises (208 Cruise Departures)
8 Day Mediterranean with France & Italy with Princess
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ships: Sun Princess, Sun Princess
Departures: May 2024 to Aug 2025
Countries Visited: Spain, Gibraltar, France, Italy
INSIDE
$1,675
OCEANVIEW
$1,873
BALCONY
$1,982
SUITE
$2,667
From 1,675
View Trip
13 Day Mediterranean Odyssey with Viking Cruises
Cruise

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+5 more), Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vela
Departures: Aug 2024 to Aug 2026
Countries Visited: Spain, France, Italy, Greece (+1 more), Croatia
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$9,895
SUITE
$14,845
Save 1,204
From 9,895
View Trip
11 Day French, Spanish & Italian Rivieras with Princess
Cruise
 (2)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Island Princess
Departure: 05 August 2024
Countries Visited: Spain, Gibraltar, France, Italy
INSIDE
-
OCEANVIEW
$2,919
BALCONY
$3,907
SUITE
$4,065
From 2,919
View Trip
8 Day Southern France and the Italian Riviera by Sea - with Smithsonian Journeys with Ponant
Cruise
 (2)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 02 October 2025
Countries Visited: Spain, France, Italy
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$8,301
SUITE
$13,907
Save 159
From 8,301
View Trip
8 Day Mediterranean with France & Italy with Princess
Cruise
 (3)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Majestic Princess
Departure: 04 March 2025
Countries Visited: Spain, Gibraltar, Corsica, Italy
INSIDE
$1,375
OCEANVIEW
-
BALCONY
$1,560
SUITE
$2,068
From 1,375
View Trip
10 Day France Intensive Voyage with Azamara Cruises
Cruise
 (1)

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 02 April 2025
Countries Visited: Spain, France, Corsica, Italy
INSIDE
$3,216
OCEANVIEW
$3,678
BALCONY
$4,368
SUITE
$6,091
From 3,216
View Trip
24 Day Mediterranean Tapestry & Empires with Holland America
Cruise
 (1)

24 Days (23 Nights) Barcelona to Venice
Cruise Line: Holland America
Ship: Oosterdam
Departure: 12 June 2024
Countries Visited: Spain, France, Italy, Sicily (+6 more), Malta, Tunisia, Greece, Turkey, Albania, Croatia
Have It All Offer
INSIDE
$7,573
OCEANVIEW
$7,781
BALCONY
$9,533
SUITE
-
From 7,573
View Trip
12 Day Around Italy's Boot: Venice Overnight with Holland America
Cruise
 (1)

12 Days (11 Nights) Barcelona to Venice
Cruise Line: Holland America
Ship: Oosterdam
Departure: 10 September 2025
Countries Visited: Spain, France, Italy, Greece (+2 more), Croatia, Montenegro
Have It All Offer
INSIDE
$3,941
OCEANVIEW
$4,139
BALCONY
$5,278
SUITE
$7,159
From 3,941
View Trip
23 Day Scenic Strands & Havens with Oceania Cruises
Cruise
 (1)

23 Days (22 Nights) Malaga to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 07 October 2025
Countries Visited: Spain, Morocco, Portugal, Tunisia (+4 more), Malta, Greece, Sicily, Italy
Exclusive Deal
INSIDE
$9,807
OCEANVIEW
$10,569
BALCONY
$15,608
SUITE
$21,152
Save 2,073
From 9,807
View Trip
13 Day Best Of The Mediterranean Voyage with Azamara Cruises
Cruise
 (1)

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 06 September 2025
Countries Visited: Spain, France, Monaco, Italy (+3 more), Montenegro, Croatia, Slovenia
INSIDE
$6,090
OCEANVIEW
$6,552
BALCONY
$7,241
SUITE
$9,540
From 6,090
View Trip
8 Day Mediterranean Spring with Oceania Cruises
Cruise
 (2)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 06 May 2025
Countries Visited: Spain, France, Monaco, Italy
Exclusive Deal
INSIDE
$4,129
OCEANVIEW
$4,357
BALCONY
$6,109
SUITE
$8,010
Save 2,031
From 4,129
View Trip
6 Day Barcelona to Rome with Silversea
Cruise

6 Days (5 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Ray
Departure: 22 June 2024
Countries Visited: Spain, France, Italy
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$10,593
From 10,593
View Trip
15 Day Italy, Spain And Adriatic with Cunard
Cruise

15 Days (14 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 17 August 2026
Countries Visited: Spain, Sardinia, Sicily, Italy (+3 more), Greece, Montenegro, Croatia
INSIDE
$3,172
OCEANVIEW
$3,518
BALCONY
$4,112
SUITE
$8,518
From 3,172
View Trip
21 Day Spain, Morocco & Mediterranean Overture with Seabourn
Cruise

21 Days (20 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Ovation
Departures: May 2025 to Oct 2025
Countries Visited: Spain, France, Gibraltar, Morocco (+4 more), Monaco, Italy, Corsica, Sardinia
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$15,418
SUITE
$28,714
From 15,418
View Trip
29 Day Mediterranean And Greek Islands with Cunard
Cruise

29 Days (28 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 04 May 2026
Countries Visited: Spain, Greece, Turkey, France (+3 more), Italy, Corsica, Sicily
INSIDE
$5,602
OCEANVIEW
$6,147
BALCONY
$7,137
SUITE
$14,859
From 5,602
View Trip
8 Day Western Mediterranean with Cunard
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 08 September 2025
Countries Visited: Spain, Sardinia, Corsica, Sicily (+1 more), Italy
INSIDE
$1,427
OCEANVIEW
$1,645
BALCONY
$1,873
SUITE
$3,833
From 1,427
View Trip
8 Day A Journey From Barcelona To Civitavecchia with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 06 October 2025
Countries Visited: Spain, France, Sardinia, Corsica (+1 more), Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$6,534
SUITE
$7,945
From 6,851
View Trip
13 Day Best Of The Mediterranean Voyage with Azamara Cruises
Cruise

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 21 April 2025
Countries Visited: Spain, France, Italy, Montenegro (+2 more), Croatia, Slovenia
INSIDE
$5,078
OCEANVIEW
$5,539
BALCONY
$6,229
SUITE
$7,953
From 5,078
View Trip
31 Day Jewels Of Spain, Italy & France with Seabourn
Cruise

31 Days (30 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Ovation
Departure: 15 April 2025
Countries Visited: Spain, Sardinia, France, Italy (+4 more), Monaco, Sicily, Malta, Corsica
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$24,432
SUITE
-
From 24,432
View Trip
21 Day France & Spanish Treasures with Seabourn
Cruise

21 Days (20 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Ovation
Departure: 10 October 2024
Countries Visited: Spain, France, Tunisia, Italy (+2 more), Sicily, Malta
More Moments On Us Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$19,126
SUITE
-
From 19,126
View Trip
8 Day Italy, France And Spain with Cunard
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departures: May 2026 to Jun 2026
Countries Visited: Spain, Corsica, Sicily, Italy
INSIDE
$1,387
OCEANVIEW
$1,585
BALCONY
$1,783
SUITE
$3,763
From 1,387
View Trip
3 Day MSC Grand Voyages with MSC Cruises
Cruise

3 Days (2 Nights) Barcelona to Rome
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 08 May 2024
Countries Visited: Spain, Italy
Best Deal Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$486
SUITE
$704
From 486
View Trip
5 Day MSC Grand Voyages with MSC Cruises
Cruise

5 Days (4 Nights) Valencia to Genoa
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 27 November 2024
Countries Visited: Spain, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
$614
BALCONY
$742
SUITE
$1,445
From 614
View Trip
8 Day A Journey From Barcelona To Civitavecchia with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departures: Jun 2025 to Sep 2025
Countries Visited: Spain, France, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$6,534
SUITE
$7,945
From 8,747
View Trip
29 Day Istanbul, Greek Islands And Mediterranean with Cunard
Cruise

29 Days (28 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 September 2026
Countries Visited: Spain, Corsica, Sicily, Italy (+3 more), France, Greece, Turkey
INSIDE
$6,246
OCEANVIEW
$6,741
BALCONY
$7,731
SUITE
$17,829
From 6,246
View Trip
5 Day Europe - Western Mediterranean with Norwegian Cruise Line
Cruise

5 Days (4 Nights) Barcelona to Rome
Ship: Norwegian Escape
Departures: May 2024 to Sep 2024
Countries Visited: Spain, France, Italy
INSIDE
$1,561
OCEANVIEW
$1,760
BALCONY
$1,990
SUITE
$2,066
From 1,561
View Trip
11 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Royal Caribbean
Ship: Voyager of the Seas
Departure: 16 May 2025
Countries Visited: Spain, Corsica, Sardinia, Sicily (+2 more), Greece, Italy
Exclusive Deal
INSIDE
$3,101
OCEANVIEW
$4,119
BALCONY
$5,231
SUITE
$6,887
Save 1,248
From 2,750
View Trip
10 Day Italian Riviera & France with Celebrity Cruises
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 03 October 2024
Countries Visited: Spain, France, Italy
Exclusive DealExclusive Offer
INSIDE
$2,491
OCEANVIEW
$2,594
BALCONY
$2,798
SUITE
$10,571
Save 3,065
From 2,407
View Trip
11 Day Europe - Western Mediterranean with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Barcelona to Venice
Ship: Norwegian Escape
Departure: 11 August 2024
Countries Visited: Spain, France, Italy, Sicily (+3 more), Malta, Greece, Croatia
INSIDE
$3,104
OCEANVIEW
$3,945
BALCONY
$4,022
SUITE
$4,480
From 3,104
View Trip
11 Day Europe - Western Mediterranean with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Barcelona to Venice
Ship: Norwegian Escape
Departure: 23 June 2024
Countries Visited: Spain, France, Italy, Sicily (+2 more), Greece, Croatia
INSIDE
$2,139
OCEANVIEW
$2,599
BALCONY
$2,674
SUITE
$3,699
From 2,139
View Trip
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