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Cruises from Italy to Spain

Are you looking for a cruise from Italy to Spain? September is the most popular month to cruise between Italy and Spain and there are 220 departures available from sixteen of the world's leading cruise lines.
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125 Cruises (220 Cruise Departures)
22 Day Istanbul, Greek Islands And Mediterranean with Cunard
Cruise

22 Days (21 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 22 September 2025
Countries Visited: Italy, Croatia, Malta, Spain (+2 more), Greece, Turkey
INSIDE
$4,145
OCEANVIEW
$4,422
BALCONY
$5,085
SUITE
$10,629
From 4,145
View Trip
29 Day Istanbul, Greek Islands And Mediterranean with Cunard
Cruise

29 Days (28 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 15 September 2025
Countries Visited: Italy, Greece, Montenegro, Croatia (+3 more), Malta, Spain, Turkey
INSIDE
$5,741
OCEANVIEW
$6,305
BALCONY
$7,058
SUITE
$15,334
From 5,741
View Trip
15 Day Adriatic And Western Mediterranean with Cunard
Cruise

15 Days (14 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departures: Jul 2024 to Aug 2024
Countries Visited: Italy, Croatia, Malta, France (+1 more), Spain
INSIDE
$2,895
OCEANVIEW
$3,192
BALCONY
$4,380
SUITE
$7,686
From 2,895
View Trip
17 Day An Extended Journey Around The Mediterranean with Explora Journeys
Cruise

17 Days (16 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 30 September 2024
Countries Visited: Italy, Sicily, Tunisia, Spain (+3 more), Gibraltar, Morocco, Portugal
Unique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$13,068
SUITE
$15,147
From 13,068
View Trip
12 Day A Journey From Rome To Barcelona with Explora Journeys
Cruise

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 23 April 2025
Countries Visited: Italy, Spain, Morocco, Gibraltar
Unique EscapesPenthouse Dream Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$8,093
SUITE
$9,875
From 8,093
View Trip
3 Day MSC Grand Voyages with MSC Cruises
Cruise

3 Days (2 Nights) Genoa to Tarragona
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 13 November 2024
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
$324
OCEANVIEW
$403
BALCONY
$492
SUITE
-
From 324
View Trip
9 Day Italy, France & Croatia Cruise with Royal Caribbean
Cruise

9 Days (8 Nights) Ravenna to Barcelona
Cruise Line: Royal Caribbean
Ship: Explorer of the Seas
Departure: 13 September 2025
Countries Visited: Italy, Croatia, France, Spain
Exclusive Deal
INSIDE
$2,133
OCEANVIEW
$3,008
BALCONY
$3,400
SUITE
$4,673
Save 830
From 1,842
View Trip
8 Day A Journey Of Limoncello Days And Catalonia Nights with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 02 September 2024
Countries Visited: Italy, Sicily, Tunisia, Spain
Exclusive DealUnique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$5,613
SUITE
$6,826
From 5,613
View Trip
8 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Ravenna to Barcelona
Cruise Line: Royal Caribbean
Ship: Voyager of the Seas
Departure: 15 September 2025
Countries Visited: Italy, Sicily, France, Spain
Exclusive Deal
INSIDE
$1,666
OCEANVIEW
$2,247
BALCONY
$2,762
SUITE
$3,223
Save 667
From 1,498
View Trip
10 Day Italy, France & Spain Cruise with Celebrity Cruises
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 24 August 2024
Countries Visited: Italy, Sicily, Malta, Corsica (+2 more), France, Spain
Exclusive DealExclusive Offer
INSIDE
$2,193
OCEANVIEW
$2,247
BALCONY
$3,336
SUITE
$7,843
Save 2,910
From 2,175
View Trip
8 Day A Journey From Civitavecchia To Barcelona with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departures: Aug 2025 to Sep 2025
Countries Visited: Italy, Sicily, Sardinia, Spain
Unique EscapesPenthouse Dream Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,846
SUITE
$7,108
From 5,846
View Trip
7 Day A Journey From Italian Piazzas To Tunisian Souks with Explora Journeys
Cruise

7 Days (6 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 30 September 2024
Countries Visited: Italy, Sicily, Tunisia, Spain (+3 more), Gibraltar, Portugal, Morocco
Exclusive DealUnique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$5,420
SUITE
$6,272
From 5,420
View Trip
8 Day A Journey From Civitavecchia To Barcelona with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departures: Jun 2025 to Sep 2025
Countries Visited: Italy, Sicily, Tunisia, Sardinia (+1 more), Spain
Unique EscapesPenthouse Dream Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,197
SUITE
$6,341
From 5,197
View Trip
10 Day Italian Riviera & France Cruise with Celebrity Cruises
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 05 August 2025
Countries Visited: Italy, France, Spain
Exclusive DealExclusive Offer
INSIDE
$2,653
OCEANVIEW
$3,214
BALCONY
$3,243
SUITE
$8,405
Save 3,549
From 2,653
View Trip
6 Day Mediterranean with MSC Cruises
Cruise

6 Days (5 Nights) Genoa to Valencia
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 05 May 2025
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
$804
OCEANVIEW
$933
BALCONY
$1,111
SUITE
$1,992
From 804
View Trip
21 Day France & Spanish Treasures with Seabourn
Cruise

21 Days (20 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Ovation
Departures: May 2025 to Jun 2025
Countries Visited: Italy, Malta, Tunisia, France (+3 more), Spain, Gibraltar, Morocco
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$15,754
SUITE
$28,713
From 15,754
View Trip
10 Day Italian Riviera & France with Celebrity Cruises
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 04 June 2024
Countries Visited: Italy, France, Spain
Exclusive DealExclusive Offer
INSIDE
$2,014
OCEANVIEW
$2,298
BALCONY
$3,020
SUITE
$7,606
Save 2,716
From 1,875
View Trip
10 Day A Journey From Civitavecchia To Barcelona with Explora Journeys
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 13 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+2 more), Sardinia, Spain
Unique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$7,049
SUITE
$8,593
From 7,049
View Trip
3 Day Mediterranean with MSC Cruises
Cruise

3 Days (2 Nights) Genoa to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 16 November 2024
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
$453
OCEANVIEW
$403
BALCONY
$492
SUITE
$829
From 403
View Trip
8 Day Central Mediterranean with Cunard
Cruise

8 Days (7 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departures: Jun 2026 to Aug 2026
Countries Visited: Italy, Croatia, Malta, Spain
INSIDE
$1,684
OCEANVIEW
$1,882
BALCONY
$2,080
SUITE
$4,456
From 1,684
View Trip
8 Day Spanish & Italian Hot Spots with Virgin Voyages
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 06 July 2025
Countries Visited: Italy, Sicily, Corsica, Spain
Up to 80% Off Second Sailor + Free Upgrade
INSIDE
$2,442
OCEANVIEW
$2,851
BALCONY
$3,145
SUITE
$6,981
From 2,442
View Trip
11 Day Riviera & Mediterranean Jewels with Seabourn
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Ovation
Departure: 10 August 2025
Countries Visited: Italy, Malta, Tunisia, France (+1 more), Spain
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$8,424
SUITE
$15,745
From 8,424
View Trip
11 Day Rome To Barcelona Cruise with Celebrity Cruises
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Constellation
Departure: 28 October 2024
Countries Visited: Italy, France, Spain
Exclusive DealExclusive Offer
INSIDE
$2,192
OCEANVIEW
$2,464
BALCONY
$2,589
SUITE
$6,572
Save 3,017
From 2,041
View Trip
10 Day Wonders Of Spain with Regent Seven Seas
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 09 May 2025
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$12,277
SUITE
$13,465
Save 5,263
From 12,277
View Trip
8 Day A Journey Of Storied Italian Islands and Starry Spanish Nights with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 19 August 2024
Countries Visited: Italy, Sicily, Sardinia, Spain
Exclusive DealUnique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$6,014
SUITE
$7,311
From 6,014
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise

15 Days (14 Nights) Naples to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 14 June 2025
Countries Visited: Italy, Sicily, Greece, Turkey (+2 more), Montenegro, Spain
INSIDE
$4,086
OCEANVIEW
$5,361
BALCONY
$5,816
SUITE
$7,351
From 4,086
View Trip
8 Day Italy, France, & Spain Cruise with Celebrity Cruises
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 10 August 2024
Countries Visited: Italy, Corsica, France, Spain
Exclusive DealExclusive Offer
INSIDE
$1,723
OCEANVIEW
$1,964
BALCONY
$2,397
SUITE
$5,406
Save 2,299
From 1,686
View Trip
15 Day Adriatic And Western Mediterranean with Cunard
Cruise

15 Days (14 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 03 August 2026
Countries Visited: Italy, Croatia, Malta, Spain (+1 more), France
INSIDE
$3,320
OCEANVIEW
$3,667
BALCONY
$4,162
SUITE
$8,914
From 3,320
View Trip
11 Day Riviera & Mediterranean Jewels with Seabourn
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Ovation
Departures: Jul 2024 to Nov 2025
Countries Visited: Italy, Malta, Tunisia, France (+1 more), Spain
The Sail Away EventMore Moments On Us Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$8,424
SUITE
$15,913
From 8,424
View Trip
8 Day Azure Summer with Regent Seven Seas
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 31 May 2025
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$9,034
SUITE
$9,766
Save 5,826
From 9,034
View Trip
Results: 31-60 of 125

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