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Cruises From Santiago

Choose from 39 unique expeditions and cruises starting in Santiago, and travelling to Buenos Aires, Cape Town, Fort Lauderdale, Guayaquil, Lima and more. February is the most popular month to join a cruise from Santiago and you can select from 112 departures available from eleven leading cruise lines.
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7 Days
33 Days
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$121,590pp
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39 Cruises (112 Cruise Departures)
33 Day Highlights of South America and Chilean Fjords Cruise with Travelmarvel
Tour + Cruise
 (1)

33 Days Santiago to Lima
Operated By: Travelmarvel
Departures: Feb 2025 to Feb 2026
Trip Styles: Coach, Group, Cruise, Scenic
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay (+2 more), Brazil, Peru
Exclusive Deal
Save 1,546
From 16,955
View Trip
18 Day South America & the Chilean Fjords with Viking Cruises
Cruise
 (3)

18 Days (17 Nights) Santiago to Buenos Aires
Cruise Line: Viking Cruises
Ship: Viking Jupiter
Departures: Nov 2024 to Feb 2026
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$9,400
SUITE
$18,805
Save 1,120
From 9,400
View Trip
16 Day Cape Horn & Strait of Magellan with Princess
Cruise
 (3)

16 Days (15 Nights) Santiago to Buenos Aires
Cruise Line: Princess
Ship: Majestic Princess
Departure: 19 December 2024
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
INSIDE
$3,922
OCEANVIEW
-
BALCONY
$5,872
SUITE
$6,337
From 3,922
View Trip
13 Day Puerto Williams to Puerto Williams with Silversea
Cruise

13 Days (12 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Wind
Departure: 04 March 2026
Countries Visited: Chile, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$21,879
BALCONY
$23,562
SUITE
$36,729
From 21,879
View Trip
13 Day Puerto Williams to Puerto Williams with Silversea
Cruise

13 Days (12 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Endeavour
Departures: Feb 2025 to Jan 2026
Countries Visited: Chile, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$26,532
From 26,532
View Trip
16 Day King George Island to Puerto Williams with Silversea
Cruise

16 Days (15 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Endeavour
Departure: 06 January 2025
Countries Visited: Chile, Antarctica, South Georgia Island, Falkland Islands
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$48,312
From 48,312
View Trip
25 Day Spirit of South America with Santiago and Galapagos Cruise with Globus
Tour + Cruise

25 Days Santiago to Guayaquil
Operated By: Globus
Departure: 12 October 2024
Trip Styles: Coach, Group, Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Chile, Brazil, Argentina, Peru (+2 more), Ecuador, Galapagos
Exclusive Savings
Save 277
From 17,883
View Trip
17 Day Cape Horn & Strait of Magellan with Princess
Cruise

17 Days (16 Nights) Santiago to Buenos Aires
Cruise Line: Princess
Ship: Sapphire Princess
Departure: 06 December 2025
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
INSIDE
$5,655
OCEANVIEW
$5,546
BALCONY
$7,922
SUITE
$9,516
From 5,546
View Trip
14 Day The Emperor Penguins of Weddell Sea with Ponant
Cruise

14 Days (13 Nights) Santiago to Santiago
Cruise Line: Ponant
Ship: Le Commandant-Charcot
Departures: Oct 2025 to Nov 2025
Countries Visited: Chile, Argentina, Antarctica
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$35,917
SUITE
$38,102
Save 796
From 35,917
View Trip
23 Day In-depth Antarctica & Patagonia Expedition (Northbound) with Hurtigruten
Cruise

23 Days (22 Nights) Santiago to Valparaiso
Cruise Line: Hurtigruten
Ship: MS Fram
Departure: 15 March 2025
Countries Visited: Chile, Antarctica
Exclusive Deal
INSIDE
-
OCEANVIEW
$51,147
BALCONY
-
SUITE
$64,968
Save 8,999
From 51,147
View Trip
19 Day Isles Of Wonder with Regent Seven Seas
Cruise

19 Days (18 Nights) Santiago to Papeete
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 16 February 2025
Countries Visited: Chile, Easter Island, French Polynesia
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$19,231
SUITE
$22,181
Save 4,279
From 19,231
View Trip
29 Day Ultimate South America with Santiago Stopover & Galapagos Cruise with Cosmos
Tour + Cruise

29 Days Santiago to Guayaquil
Operated By: Cosmos
Departures: Sep 2024 to Nov 2025
Trip Styles: Coach, Group, Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Chile, Brazil, Argentina, Peru (+2 more), Ecuador, Galapagos
Exclusive Savings
From 15,361
View Trip
22 Day Puerto Williams to Cape Town with Silversea
Cruise

22 Days (21 Nights) Santiago to Cape Town
Cruise Line: Silversea
Ship: Silver Wind
Departure: 16 March 2026
Countries Visited: Chile, Falkland Islands, South Georgia Island, South Africa
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$17,622
BALCONY
$21,087
SUITE
$28,512
From 17,622
View Trip
20 Day Panama Canal & the Americas with Viking Cruises
Cruise

20 Days (19 Nights) Santiago to New York
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Mar 2026 to Mar 2026
Countries Visited: Chile, Peru, Panama, Jamaica (+1 more), Bahamas
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$17,815
SUITE
$25,735
Save 1,180
From 17,815
View Trip
30 Day Best of South America with Amazon and Galapagos Cruises with APT
Tour + Cruise

30 Days Santiago to Guayaquil
Operated By: APT
Ship: Delfin III
Departures: Apr 2025 to Sep 2025
Trip Styles: Coach, Group, Cruise, River Cruise, Island Hopping, Scenic
Countries Visited: Chile, Argentina, Brazil, Peru (+2 more), Ecuador, Galapagos
Exclusive Deal
Save 2,739
From 39,656
View Trip
14 Day Patagonian Shores & Chilean Fjords with Viking Cruises
Cruise

14 Days (13 Nights) Santiago to Buenos Aires
Cruise Line: Viking Cruises
Ship: Viking Octantis
Departure: 11 November 2024
Countries Visited: Chile, Argentina
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$14,845
SUITE
$20,785
Save 1,150
From 14,845
View Trip
13 Day Chilean Fjords & Scenic Shores with Viking Cruises
Cruise

13 Days (12 Nights) Santiago to Buenos Aires
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Nov 2024 to Oct 2025
Countries Visited: Chile, Argentina
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$13,855
SUITE
$19,795
Save 1,140
From 13,855
View Trip
11 Day Puerto Williams to Ushuaia with Silversea
Cruise

11 Days (10 Nights) Santiago to Ushuaia
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 06 March 2026
Countries Visited: Chile, Antarctica, Argentina
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
$16,929
BALCONY
$19,998
SUITE
$43,758
From 16,929
View Trip
23 Day Puerto Williams to Valparaiso with Silversea
Cruise

23 Days (22 Nights) Santiago to Valparaiso
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 06 March 2026
Countries Visited: Chile, Argentina, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$26,433
BALCONY
$30,888
SUITE
$50,193
From 26,433
View Trip
17 Day Edge Of The World Expedition with Regent Seven Seas
Cruise

17 Days (16 Nights) Santiago to Buenos Aires
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 01 February 2026
Countries Visited: Chile, Argentina, Uruguay
Land Package Credit
INSIDE
-
OCEANVIEW
-
BALCONY
$18,481
SUITE
$20,115
Save 8,169
From 18,481
View Trip
29 Day Best of South America with Amazon and Galapagos Cruises with APT
Tour + Cruise

29 Days Santiago to Guayaquil
Operated By: APT
Ships: Delfin III
Departure: 14 September 2024
Trip Styles: Coach, Group, Cruise, River Cruise, Island Hopping, Scenic
Countries Visited: Chile, Argentina, Brazil, Peru (+2 more), Ecuador, Galapagos
Exclusive Savings
Save 604
From 34,791
View Trip
11 Day Puerto Williams to Puerto Williams with Silversea
Cruise

11 Days (10 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Wind
Departures: Dec 2024 to Feb 2026
Countries Visited: Chile, Antarctica
Mutiple Deals Available
INSIDE
-
OCEANVIEW
$20,889
BALCONY
$22,968
SUITE
$29,403
From 20,889
View Trip
23 Day In-depth Antarctica, Falklands & South Georgia Expedition with Hurtigruten
Cruise

23 Days (22 Nights) Santiago to Santiago
Cruise Line: Hurtigruten
Ship: MS Fram
Departures: Nov 2024 to Feb 2026
Countries Visited: Chile, Falkland Islands, South Georgia Island, Antarctica
Exclusive Deal
INSIDE
$25,363
OCEANVIEW
$27,699
BALCONY
-
SUITE
$36,827
Save 10,673
From 25,363
View Trip
16 Day Puerto Williams to Puerto Williams with Silversea
Cruise

16 Days (15 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Endeavour
Departure: 22 December 2025
Countries Visited: Chile, South Georgia Island, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$36,234
From 36,234
View Trip
11 Day Puerto Williams to Puerto Williams with Silversea
Cruise

11 Days (10 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Cloud
Departures: Nov 2024 to Nov 2025
Countries Visited: Chile, Antarctica
Mutiple Deals Available
INSIDE
-
OCEANVIEW
$20,790
BALCONY
$22,176
SUITE
$27,621
From 20,790
View Trip
22 Day Puerto Williams to Buenos Aires with Silversea
Cruise

22 Days (21 Nights) Santiago to Buenos Aires
Cruise Line: Silversea
Ship: Silver Endeavour
Departure: 10 March 2025
Countries Visited: Chile, Argentina, Falkland Islands, Antarctica
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$33,462
From 33,462
View Trip
18 Day San Antonio To Fort Lauderdale with Cunard
Cruise

18 Days (17 Nights) Santiago to Fort Lauderdale
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 25 February 2025
Countries Visited: Chile, Peru, Ecuador, Panama (+3 more), Aruba, Bahamas, USA
INSIDE
$4,658
OCEANVIEW
$5,450
BALCONY
$7,232
SUITE
$16,340
From 4,658
View Trip
11 Day Puerto Williams to Puerto Williams with Silversea
Cruise

11 Days (10 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Endeavour
Departures: Nov 2025 to Mar 2026
Countries Visited: Chile, Antarctica
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$23,364
From 23,364
View Trip
32 Day San Antonio To Southampton with Cunard
Cruise

32 Days (31 Nights) Santiago to London
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 25 February 2025
Countries Visited: Chile, Peru, Ecuador, Panama (+6 more), Aruba, Bahamas, USA, Bermuda, Portugal, England
INSIDE
$7,237
OCEANVIEW
$8,524
BALCONY
$11,098
SUITE
$25,552
From 7,237
View Trip
19 Day Puerto Williams to Puerto Williams with Silversea
Cruise

19 Days (18 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Wind
Departures: Dec 2024 to Dec 2025
Countries Visited: Chile, Falkland Islands, South Georgia Island, Antarctica
Mutiple Deals Available
INSIDE
-
OCEANVIEW
$33,264
BALCONY
$36,036
SUITE
$52,470
From 33,264
View Trip
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