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Cruises From Panama City

Choose from 16 unique cruises starting in Panama City, and travelling to Fort Lauderdale, Galveston, Los Angeles, Miami, New York and more. December and February are the most popular months to join a cruise from Panama City and you can select from 20 departures available from seven leading cruise lines.
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16 Cruises (20 Cruise Departures)
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (4)

11 Days (10 Nights) Panama City to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Oct 2024 to Dec 2025
Countries Visited: Panama, Costa Rica, Honduras, Belize (+2 more), Mexico, USA
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$5,638
SUITE
$8,905
Save 1,074
From 5,638
View Trip
11 Day Captivating Panama Canal with Oceania Cruises
Cruise
 (2)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 02 April 2025
Countries Visited: Panama, Colombia, Aruba, Curacao (+3 more), Bonaire, Jamaica, USA
Exclusive Deal
INSIDE
$5,147
OCEANVIEW
$5,533
BALCONY
$7,751
SUITE
$10,285
Save 2,033
From 5,147
View Trip
12 Day Classic Panama Canal with Oceania Cruises
Cruise
 (2)

12 Days (11 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 18 February 2025
Countries Visited: Panama, Colombia, Aruba, Curacao (+4 more), Bonaire, Jamaica, Bahamas, USA
Exclusive Deal
INSIDE
$5,931
OCEANVIEW
$6,386
BALCONY
$8,831
SUITE
$17,335
Save 2,039
From 5,931
View Trip
12 Day Panama Canal - Panama City with Norwegian Cruise Line
Cruise

12 Days (11 Nights) Panama City to Galveston
Ship: Norwegian Jade
Departure: 26 January 2026
Countries Visited: Panama, Colombia, Jamaica, Cayman Islands (+4 more), Honduras, Belize, Mexico, USA
Free At Sea Offer
INSIDE
$3,254
OCEANVIEW
$3,786
BALCONY
$5,152
SUITE
$5,654
From 3,254
View Trip
11 Day Classic Canal & Tropics with Oceania Cruises
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 04 April 2026
Countries Visited: Panama, Colombia, Curacao, Aruba (+3 more), Jamaica, Cayman Islands, USA
Exclusive Deal
INSIDE
$5,026
OCEANVIEW
$5,482
BALCONY
$7,927
SUITE
$10,927
Save 2,034
From 5,026
View Trip
11 Day Canal & Coral Isles with Oceania Cruises
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 24 April 2026
Countries Visited: Panama, Colombia, Costa Rica, Honduras (+2 more), Mexico, USA
Exclusive Deal
INSIDE
$5,026
OCEANVIEW
$5,482
BALCONY
$7,927
SUITE
$10,927
Save 2,034
From 5,026
View Trip
11 Day Tropical Tastes Of The Riviera with Regent Seven Seas
Cruise

11 Days (10 Nights) Panama City to Los Angeles
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 15 January 2026
Countries Visited: Panama, Costa Rica, Nicaragua, Mexico (+1 more), USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$9,618
SUITE
$10,143
Save 6,132
From 9,618
View Trip
12 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

12 Days (11 Nights) Panama City to Miami
Ship: Norwegian Jade
Departure: 09 February 2025
Countries Visited: Panama, Colombia, Aruba, Curacao (+4 more), Saint Kitts and Nevis, Virgin Islands, Dominican Republic, USA
Free At Sea Offer
INSIDE
$2,795
OCEANVIEW
$3,312
BALCONY
$4,814
SUITE
$5,118
From 2,795
View Trip
14 Day Panama Canal - Panama City with Norwegian Cruise Line
Cruise

14 Days (13 Nights) Panama City to New York
Ship: Norwegian Jade
Departure: 22 December 2025
Countries Visited: Panama, Colombia, Aruba, Curacao (+5 more), Saint Lucia, Saint Kitts and Nevis, Virgin Islands, Dominican Republic, USA
Free At Sea Offer
INSIDE
$4,519
OCEANVIEW
$5,278
BALCONY
$7,176
SUITE
$8,315
From 4,519
View Trip
10 Day Panama Canal - Panama City with Norwegian Cruise Line
Cruise

10 Days (9 Nights) Panama City to Miami
Ship: Norwegian Gem
Departure: 11 December 2024
Countries Visited: Panama, Costa Rica, Jamaica, Cayman Islands (+3 more), Mexico, Bahamas, USA
Free At Sea Offer
INSIDE
$2,400
OCEANVIEW
$2,703
BALCONY
$3,796
SUITE
$4,010
From 2,400
View Trip
11 Day Panama Canal - Panama City with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Panama City to Miami
Ship: Norwegian Jade
Departure: 10 November 2025
Countries Visited: Panama, Colombia, Jamaica, Cayman Islands (+4 more), Honduras, Belize, Mexico, USA
Free At Sea Offer
INSIDE
$3,073
OCEANVIEW
$3,530
BALCONY
$4,743
SUITE
$5,124
From 3,073
View Trip
10 Day Panama Canal Voyage with Azamara Cruises
Cruise

10 Days (9 Nights) Panama City to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 13 December 2024
Countries Visited: Panama, Costa Rica, Honduras, Guatemala (+2 more), Mexico, USA
Circle Club Voyage
INSIDE
$2,943
OCEANVIEW
$3,043
BALCONY
$3,820
SUITE
$5,372
From 2,943
View Trip
11 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Panama City to Tampa
Ship: Norwegian Jade
Departure: 19 January 2025
Countries Visited: Panama, Colombia, Jamaica, Cayman Islands (+4 more), Honduras, Belize, Mexico, USA
Free At Sea Offer
INSIDE
$2,650
OCEANVIEW
$2,910
BALCONY
$4,291
SUITE
$4,564
From 2,650
View Trip
12 Day Panama Canal - Panama City with Norwegian Cruise Line
Cruise

12 Days (11 Nights) Panama City to Miami
Ship: Norwegian Jade
Departure: 16 February 2026
Countries Visited: Panama, Colombia, Aruba, Saint Lucia (+4 more), Saint Kitts and Nevis, Virgin Islands, Dominican Republic, USA
Free At Sea OfferExclusive Solo Offer
INSIDE
$3,222
OCEANVIEW
$3,754
BALCONY
$5,227
SUITE
$5,622
From 3,222
View Trip
8 Day A Journey Traversing The Panama Canal with Explora Journeys
Cruise

8 Days (7 Nights) Panama City to Miami
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 24 May 2024
Countries Visited: Panama, Colombia, USA
Exclusive DealThe Total Luxury Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,593
SUITE
$6,519
From 5,593
View Trip
12 Day The Panama Canal & Costa Rica - Westbound with Tauck
Cruise

12 Days (11 Nights) Panama City to San Jose
Operated By: Tauck
Departure: 18 January 2025
Trip Styles: Group, Cruise
Countries Visited: Panama, Costa Rica
From 14,250
View Trip
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